Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-03-05
1999-09-14
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514424, 514425, 514426, 514428, 548541, 548543, 548556, 548557, 548566, 548570, A61K 3140, C07D20709, C07D20712, C07D20714
Patent
active
059523638
ABSTRACT:
The present invention relates to novel pyrrolidine compounds having the general formula I ##STR1## and pharmaceutically acceptable acid addition salts or hydrates or prodrugs thereof, wherein R.sup.1 is straight or branched C.sub.1-14 -alkyl optionally substituted with C.sub.3-7 -cycloalkyl, C.sub.1-6 -alkoxy, phenoxy, perhalomethyl, halogen, optionally substituted phenyl;
REFERENCES:
patent: 4996329 (1991-02-01), Fleet et al.
Fairbanks et al., Tetrahedron, vol. 48, No. 16, pp. 3365-3376 (1992).
Brandstetter et al., Tetrahedron Letter, vol. 36, No. 41, pp. 7511-7514, (1995).
Winchester et al., Biochem J., vol. 290, pp. 743-749 (1993).
Kimura et al., Journal of Traditional Medicines, vol. 12, pp. 214-219 (1995).
Fairbanks et al., "Synthesis of, and Lack of Inhibition of a Rhamnosidase by, Both Enantiomers of Deoxyrhamnojirimycin and Rhamnonolactam: Beta-Mannosidase Inhibition by Gamma-lactams," Tetrahedron, vol. 48, No. 16, pp. 3365-3376, Apr. 17, 1992.
Jakobsen Palle
Kristiansen Marit
Lundbeck Jane Marie
Gregg Valeta A.
Novo Nordisk A S
Oswecki Jane C.
Richter Johann
Rozek Carol E.
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