Monoclonal antibodies specific for a human mononculear phagocyte

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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530387, 530388, 435 7021, 4351722, C12N 520, C07K 1528, C12P 2108

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active

050772163

ABSTRACT:
A 155 kDa phagocyte-specific antigen which is expressed on human monocytes, monocyte-derived macrophages and peritoneal macrophages, but is not expressed on human granulocytes, lymphocytes and platelets is described.

REFERENCES:
patent: 4701408 (1987-10-01), Koestler
Griffin et al., "Expression of Myeloid Differentation Antigens on Normal and Malignant Myeloid Cells", J. Clin. Invest., 68, 932-941, (1981).
Talle, et al., "Patterns of Antigenic Expression on Human Monocytes as Defined by Monoclonal Antibodies", Cell. Immunol., 78, 83-99 (1983).
Sanchez-Madrid et al., "A Human Leukocyte Differentiation Antigen Family with Distinct a-Subunits and a Common b-Subunit", J. Exp Med., 158, 1785-1803, (1983).
Lanier et al., "pl50/95, Third member of the LFA-1/CR.sub.3 polypeptide family identified by anti-Leu M5 monoclonal antibody", Eur. J. Immunol., 15, 713-718, (1985).
Look et al., "Transfer and Expression of the Gene Encoding a Human Myeloid Membrane Antigen (gp150), " J. Clin. Invest, 75: 569-579 (1985).
Schwarting et al., "The Monoclonal Antibodies aS-HCL 1 (aLeu-14) and aS-HCL 3 (aLeu-M5) Allow the Diagnosis of Hairy Cell Leukemia", Blood, 65(4), 974-983 (1985).
Takaishi et al., "Monoclonal Antibodies Against Human Myelomonocytic Cells: Detection of Certain Lineage-Specific Antigens on CFU-GM Progenitor Cells", J. Immunol., 135(2), 1523-1529 (1985).
Goyert et al., "Biochemistry and Expression of Myelomonocytic Antigens", J. Immunol., 137(12): 3909-3914 (1986).
Hynes, "Integrins: A Family of Cell Surface Receptors", Cell, 48:549-554 (1987).
Hogg et al., Ciba Foundation Symposium 118 (Biochem Macrophage) pp. 68-80, 1986.

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