DNA encoding a human progesterone receptor complex p23-like prot

Details DNA encoding a human progesterone receptor complex p23-like prot DNA encoding a human progesterone receptor complex p23-like prot

1997-10-09

1999-09-14

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435 691, 435455, 435471, 435325, 4352523, 4353201, 536 235, 536 243, C12Q 168, C12P 1934, C07H 2104

Patent

active

059521759

ABSTRACT:
The invention provides a human progesterone receptor complex p23-like protein (PR23P) and polynucleotides which identify and encode PR23P. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating and preventing disorders associated with expression of PR23P.

REFERENCES:
Brody et al., Genomics 25, 238-247 (1995).
Miki et al., Science 266, 66-71 (1994).
Johnson, J.L. et al., "Characterization of a Novel 23-Kilodalton Protein of Unactive Progesterone Receptor Complexes", Mol. Cell. Biol., 14: 1956-1963 (1994) (GI 438652).
Moutsatsou, P. and C.E. Sekeris, "Estrogen and Progesterone Receptors in the Endometrium", Ann. N.Y. Acad. Sci., 816: 99-115 (1997).
Kang, K.I. et al., "In vivo functional protein-protein interaction. Nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus", Proc. Natl. Acad. Sci. USA, 91: 340-344 (1994).
Smith, D.F. et al., "Progesterone Receptor Structure and Function Altered by Geldanamycin, an hsp90-Binding Agent", Mol. Cell. Biol., 15: 6804-6812 (1995).
Elledge, R.M. et al., "p53 Protein Accumulation Detected by Five Different Antibodies: Relationship to Prognosis and Heat Shock Protein 70 in Breast Cancer", Cancer Res., 54: 3752-3757 (1994).
Johnson, J.L. et al., (Direct Submission), GenBank Sequence Database (Accession L24804; L24805), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 438651; GI 438652).

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