Biocompatible stable fluorocarbon emulsions for contrast enhance

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 77, 514 78, 514723, 514744, 514747, 514759, 514832, 514887, 514941, 514943, A61K 4904, A61K 31685, A61K 3108, A61K 31035

Patent

active

050770365

ABSTRACT:
Biocompatible fluorcarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen.

REFERENCES:
patent: 3818229 (1974-06-01), Long, Jr.
patent: 3975512 (1976-08-01), Long
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4105798 (1978-08-01), Moore et al.
patent: 4116336 (1978-09-01), Sorensen et al.
patent: 4146499 (1979-03-01), Rosano
patent: 4151108 (1979-04-01), Sorensen et al.
patent: 4163734 (1979-08-01), Sorensen et al.
patent: 4232665 (1980-11-01), Vaseen
patent: 4299215 (1981-11-01), Anon
patent: 4299728 (1981-11-01), Cormier et al.
patent: 4369127 (1983-01-01), Cormier et al.
patent: 4397870 (1983-08-01), Sloviter
patent: 4423077 (1983-12-01), Sloviter
patent: 4769241 (1988-09-01), Heldebrant et al.
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4927623 (1990-05-01), Long, Jr.
Riess, J. G., "Reassessment of Criteria for the Selection . . . Relationships", Artificial Organs, 8(1):49 (1984).
Mottram, J. C., "On the Alteration in the Sensitivity of Cells . . . Aerobiosis" British Journal of Radiology 8:32 (1935).
Davis, S., "The Stability of Fat Emulsions . . .", Advances in Clinical Nutrition, (I.D.A. Johnston, Ed.) MTP Press, Ltd. Boston, pp. 213-239 (1982).
Goodin et al., "A Method for Evaluation of Blood Substitutes in the Conscious Animal", American Journal of Physiology 245:H519-523 (1983).
Geyer, R., "Perfluorocarbon Blood Substitutes", Proceedings of Int'l Symp. on Artificial Blood Substitutes, Bari, Italy: 06/19-20/87, pp. 45-67.
Persico et al., "A General Synthesis for Symmetrical Highly Branched Perfluoro Ethers: A New Class of Oxygen Carriers", J. Org. Chem. 50:5156-5159 (1985).
Sharts, C. and Reese, H., "The Solubility of Oxygen in Aqueous Fluorocarbon Emulsions", J. Fluorine Chem. 11:637-641 (1978).
Yokoyama, K. et al., "Preparation of Perfluorodecalin Emulsion, an Approach to the Red Cells Substitute", Fed. Proc. 34(6):1478-1483 (1975).
Steiner, M. and Anastasi, J., "Vitamine An Inhibitor of the Platelet Release Reaction", J. Clin. Invest. 57:732-737 (1976).
Pandolfe, W. D. and Kinney, R. R., "Recent Developments in . . . Homogenization Parameters", Nat'l Mtg. of Amer. Inst. of Chem. Eng., Denver, Colo. (08/29/83).
Gould, S. A. et al., "Assessment of a 35% Fluorocarbon Emulsion", The J. of Trauma 23(8):720-724 (1983).
Moss, G. et al., "Polyhemoglobin and Fluorocarbon as Blood Substitutes", Biomat., Art. Cells, Art. Org. 15(2):333-336 (1987).
Geyer, R. P., "Perfluorochemicals as Oxygen Transport Vehicles", Biomat., Art. Cells, Art. Org. 15(2):329-332 (1987).
Burgan, A. R. et al., "Results of Pharmacokinetic and Toxicologic Studies With PFOB Emulsions", Biomat., Art. Cells, Art. Org. 15(2):403 (1987).
Long, D. C. et al., "Preparation and Applications of Highly Concentrated PFOB Emulsions", Biomat., Art. Cells, Art. Org. 15(2):417-418 (1987).
Police, A. M. et al., "Pulmonary Complications After Fluosol Administration to Patients with Life-Threatening Blood Loss", Critical Care Medicine 13(2):96-98 (1985).
Bose, B. et al., "Focal Cerebral Ischemia: Reduction in Size of Infarcts by Ventriculo-Subarachnoid Perfusion with Fluorocarbon Emulsion", Brain Res. 328:223-231 (1985).
Spears, J. et al., "Myocardial Protection with Fluosol-DA During Prolonged Coronary Balloon Occlusion in the Dog", Circulation (Abstracts 68(Supp. III):No. 317 (Oct. 1983).
Nunn, Ogilby, J. et al., "Effect of Perfluoroctylbromide on Ischemic Myocardium", 60th Scientific Session, American Heart Assoc., (11/16-19/87).
Nunn, G. R. et al., "Effect of Fluocarbon Exchange Transfusion on Myocardial Infarction Size in Dogs", Amer. J. of Cardio, 52:203-205 (1983).
Patel, M. et al., "Survival and hHistopathologic Changes in Lungs of Hamsters Following Synthetic Liquid Breathing", Fed. Proceedings 29(5):1740-1745 (1970).
Itoh, Y. et al., "Radiosensitization by the Oxygen Effect of Artificial Blood (FOB 20%) in Ehrlich-Tumor Mice", Gan to Kagaku Ryoho 11(4):864-72 (1984).
Rockwell, S., "Perfluorochemical Emulsions as Adjuncts to Radiotherapy", Biomat., Art. Cells, Art. Org. 15(2):430 (1987).
Dobben, G. D. et al., "Experimental Studies with Radiopaque Fluorocarbon in the Subarachnoid Space", Neuroradiology 6:17-19 (1973).
Peck, W. W. et al., "Perfluorocytylbromide Acute Hemodynamic Effects, in Pigs, of Intravenous Administration Compared With the Standard Ionic Contrast Media", Invest Radiology 19:129-132 (1984).
Brahme, F. et al., "Perfluoro Carbon Bromides as Contrast Media in Radiography of the Central Nervous System", Acta Radiologica Supp. 347:459-466 (1975).
Liu, M. S. et al., "Myelography with Perfluoroctylbromide: Comparison with Pantopaque", Invest. Radiology 11(4):319-330 (1976).
Long, D. M. et al., "Efficacy and Toxicity Studies with Radiopaque Perfluorocarbon", Radiology 105(2):323-332 (1972).
Mattrey, R. F. et al., "Perfluorochemicals as U.S. Contrast Agents for Tumor Imaging and Hepatosplenography: Preliminary Clinical Resuls", Radiology 163:339-343 (1987).
Mattrey, R. F., "Ultrasound Enhancement of Tissues During the Capillary Phase of PFOB-100% Immediately Post Infusion", 35th Annual Mtg. of Assoc. Univ. Radiologists Charleston, SC (Mar. 22-27, 1987).
Arlen, C. et al., "Formulation of Highly Concentrated Fluorocarbon Emulsions and Assessment by Near-Total Exchange Perfusion of the Conscious Rat", Biomat., Art. Cells, Art. Org. 15(2):431 (1987).
Burgan, A. R. et al., "Acute and Subacute Toxicity of 100% PFOB Emulsion", presented 5th Ann. Mtg. Soc. Mag. Resonance in Med., Montreal (Aug. 18-22, 1986).
Long, D. et al., "Total Exchange Perfusion of Rats with Highly Concentrated Fluorocarbon Emulsions", Int'l Symposium, Centenary of the Discovery of Fluorine, Paris, (Aug. 25-29, 1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Biocompatible stable fluorocarbon emulsions for contrast enhance does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biocompatible stable fluorocarbon emulsions for contrast enhance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible stable fluorocarbon emulsions for contrast enhance will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1508592

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.