Polysaccharide vaccine to enhance immunity against brucellosis

Details Polysaccharide vaccine to enhance immunity against brucellosis Polysaccharide vaccine to enhance immunity against brucellosis

1996-09-16

1999-09-14

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241841, 42419711, 4242341, 4242351, 4242411, 4242491, 4242551, 4242561, 4242571, 4242581, 4242601, 4242611, 514 54, 536123, 5361231, 536127, 536 111, A61K 3910, A61K 3902

Patent

active

059519878

ABSTRACT:
A vaccine comprising purified outer-polysaccharide (OPS) is effective for protection against brucellosis. The vaccine is derived from Brucella or a variety of cross reactive bacteria. The vaccine can be administered by different routes (intramuscularly, subcutaneously, intraperitoneally, orally). The vaccine is effective in protecting against other infectious bacteria, aside from Brucella. It is likely that the vaccine can be given after infection to reduce illness.

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"Antigens of Brucella" by J. Cherwonogrodzky et al, pp. 19-64, In: K. Nielsen, J.R. Duncan (ed.) 1990 Animal Brucellosis CRC Press, Boca Raton mentioned on p. 4 of the application.
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"Laboratory Animal Models for Brucellosis Studies" by Casimiro Garcia-Carrillo pp. 423 to 442, In: K Nielsen, J.R. Duncan (ed) 1990 Animal Brucellosis (mentioned on p. 9 of the application).
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P. Nicoletti et al. "The Immune response to B. Abortus: . . . " Animal Brucellosis, Chapter 4, pp. 83-95, 1990.
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