Process for preparing pyrrolizine derivatives

Details Process for preparing pyrrolizine derivatives Process for preparing pyrrolizine derivatives

1994-11-30

1996-07-02

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548465, C07D45100, C07D48704

Patent

active

055323812

ABSTRACT:
This invention relates to novel processes for preparing substituted pyrrolizine compounds. More particularly, it relates to novel processes for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylate of the following formula (I) from pyrrole. ##STR1##

REFERENCES:
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patent: 4347486 (1982-08-01), Muchowski et al.
patent: 4496741 (1985-01-01), Doherty
patent: 5082950 (1992-01-01), Muchowski et al.
patent: 5082951 (1992-01-01), Muchowski et al.
J. Med. Chem., 1985, vol. 28, pp. 1037-1049; J. M. Muchowski et al.: Synthesis and Antiinflammatory and Analgesic Activity of 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic Acids and Related Compounds.
Can. J. Chem., vol. 60, 1982, pp. 2295-2312; Humberto Caprio et al.: Synthesis of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and homologous pyridine and azepine analogues thereof.
J. Org. Chem., vol. 47, 1982, pp. 1682-1688; Fidencio Franco et al.: Novel Syntheses of -Aroyl-1,2-dihydro-3H-pyrrole[1,2-a]pyrrole-1-carboxylic Acids.
J. Org. Chem., vol. 44, No. 24, 1979, pp. 4410-4419; Bruce E. Maryanoff: Carbenoid Chemistry, Reaction with Pyrrole Derivatives with Ehtyl Diazoacetate.
J. Org. Chem., vol. 42, No. 26, 1977, pp. 4248-4251; Julian White et al.: The Vilsmeier-Haack Aroylation of Pyrroles Reexamined.

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