Treatment of central nervous system inflammatory disease with ma

Details Treatment of central nervous system inflammatory disease with ma Treatment of central nervous system inflammatory disease with ma

1994-11-30

1996-07-02

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31405

Patent

active

055322654

ABSTRACT:
A synthetic inhibitor of matrix metalloproteases, the tripeptide hydroxamate GM 6001, is administered to a patient suffering from an inflammatory disease of the central nervous system wherein the effect is mediated primarily through restoration of the blood-CNS barrier.

REFERENCES:
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patent: 5270326 (1993-12-01), Galardy et al.
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Gijbels, et al., Gelatinase B is Present in the Cerebrospinal Fluid During Experimental Autoimmune Encephalomyelitis and Cleaves Myelin Basic Protein, Journal of Neuroscience Research 36:432-440 (1993).
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Grobelny, et al., Inhibition of Human Skin Fibroblast Coolagenase, Thermolysin, and Pseudomonas Aeruginosa Elastase B Peptide Hydroxamic Acids, Biochemistry, vol. 31, No. 31, 76152-54 (1992).
Galardy, et al., Low Molecular Weight Inhibitors in Corneal Ulceration, Annals New York Academy of Sciences, 732:315-323 (1994).
Schultz, et al., Treatment of Alkali-Injured Rabbit Corneas With a Synthetic Inhibitor of Matrix Metalloproteinases, Investigative Ophthalmology & Visual Science, vol. 33, No. 12, 3325-3331 (Nov. 1992).
Galardy, et al., Inhibition of Angiogenesis by the Matrix Metalloprotease Inhibitor N-[2R-2-(Hydroaxamidocarbonymethyl)-4-Methylpentanoyl)]-L-Tryptophan Methylamide, Cancer Research 54, 4715-4718 (Sep. 1, 1994).
Bendeck, et al., Smooth Muscle Cell Migration and Matrix Metalloproteinase Expression After Arterial Injury in the Rat, Circulation Research, vol. 75, No. 3 (Sep. 1994).

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