Cyclic nitrones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514213, 514217, 514278, 514409, 514416, A61K 3147

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active

055322522

ABSTRACT:
The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.

REFERENCES:
patent: 3044930 (1962-07-01), Goodhue
patent: 3795715 (1974-03-01), Leimgruber et al.
patent: 3947451 (1978-09-01), Josson et al.
patent: 4117144 (1978-09-01), Josson et al.
patent: 4123543 (1978-09-01), Josson et al.
patent: 5025032 (1991-06-01), Carney et al.
Floyd, FASEB Journal, vol. 4, pp. 2587-2599 (1990).
Bolli et al., Free Rad. Res. Comm, vol. 9, Nos. 3-6, pp. 169-180, 1990.
Goluber et al, Chemical Abstracts, vol. 77, No. 16, Abstract 114.165c, Oct. 16, 1972, pp. 428-429.
Kobor, "Chemical Abstracts, " vol. 77, 1972, Col. 151841r.
Jonsson, et al., "Chemical Abstracts," vol. 78, 1973, Col. 159460g.
Patent Abstracts of Japan vol. 12, No. 283 (C-518)(3130) 3 Aug. 1988 & JP-A-63 063 851 (Univ. Osaka) 22 Mar. 1988.
Interleukin-1 and Interleukin-1 Antagonism, Blood, vol. 77, No. 8 (Apr. 15), 1991: pp. 1627-1652, Charles A. Dinarello.
An Unanesthetized-Gerbil Model of Cerebral Ischemia-induced Behavioral Changes, Journal of Pharmacological Methods 14, 137-146 (1985) Chandler, et al.
A Modified Bischler-Napieralski Procedure for the Synthesis of 3-Aryl-3,4-dihydroisoquinolines, J. Org. Chem. 1991, 56, 6034-6038, Larsen et al.
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-.alpha.-phenylnitrone, Proc. Natl. Acad. Sci. USA vol. 88, pp. 3633-3636, May 1991 Neurobiology, Carney et al.
Tungstate-Catalyzed of Secondary Amines to Nitrones. .alpha.-Substitution of Secondary Amines via Nitrones; J. Org. Chem. 1990, 55, 1736-1744.
Baggiolini, M. et al, Chemical Abstracts vol. 111, No. 25 Abstract 230.179e, p. 565, Dec. 18, 1989.
Dinarello, et al, Chemical Abstracts vol. 105, No. 21, Abstract 189195t, p. 591, Nov. 24, 1986.
Oxidative damage to brain proteins, loss of glutamin synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain, Proc. Natl. Acad. Sci. USA vol. 87, pp. 5144-5147 Jul. 1990, Neurobiology.
Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-a-phenylnitrone (PBN) Neuroscience Letters, 116 (1990) 315-319.
Seeger, et. al., "Chem. Ber.", vol. 103, 1970, pp. 1674-1691.
Thomae, "ChemicaL Abstracts," vol. 74, 1971, Col 141572c.

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