Antiviral carbocyclic analogs of xylofuranosylpurines

Details Antiviral carbocyclic analogs of xylofuranosylpurines Antiviral carbocyclic analogs of xylofuranosylpurines

1985-09-10

1988-05-03

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544276, 544277, 514261, 514262, C07D47332, A61K 3152

Patent

active

047420642

ABSTRACT:
Biologically-active (6-amino) purine nucleosides of the formula: ##STR1## are disclosed wherein X is CH or N, and R is selected from the group consisting of N(Y)(Z), SY, OY and halogen, wherein Y and Z are H, lower(alkyl), phenyl or mixtures thereof; and the pharmaceutically-acceptable salts thereof. The compounds exhibit antiviral and antitumor activity.

REFERENCES:
patent: 4138562 (1979-02-01), Vince
patent: 4383114 (1983-05-01), Vince
patent: 4543255 (1985-09-01), Sheally
H. Lee and R. Vince, J. Pharm. Sci., 69, 1019 (1980).
R. Vince et al., J. Med. Chem. 27, 1358 (1984).
R. Vince et al., J. Med. Chem., 20, 612 (1977).
L. B. Townsend, in Nucleoside Analogues-Chemistry, Biology and Medical Applications, R. T. Walker, E. DeClerq and F. Eckstein, Eds., Plenum Press, NY (1979), at pp. 193-223.
R. Vince et al., Science, 221, 1405 (1983).

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