Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-08-15
1996-01-23
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3135
Patent
active
054865360
ABSTRACT:
Using in vitro adhesion of recombinant rat L-selectin-Ig or rat neutrophils, it has been demonstrated that these materials bind to sulfatide that has been present in solid phase on a plastic surface. The binding activity appears to have structural requirements, with the sulfate group being critically present in position 3 on the pyranose ring of galactose. When used in vivo, it has been demonstrated that sulfated glycolipids such as brain sulfatide and ganglioside, have significantly protective effects in two models of lung inflammation, the first systemic activation of complement and the second occurring after intrapulmonary deposition of immune complexes. Both inflammatory reactions are complement, neutrophil and selectin-dependent. The protective effects of these compounds are linked to their ability to prevent the recruitment of neutrophils into lung tissue. On the basis of these findings, it is demonstrated by sulfatides and related compounds have significant in vivo anti-inflammatory activities. These compounds thus represent a new class of anti-inflammatory agents.
REFERENCES:
Mulligan et al, "Neutrophil-dependent Acute Lung Injury", J. Clin. Invest., vol. 90, Oct. 1992, pp. 1600-1607.
Mulligan et al, "Protective Effects of IL-4 and IL-10 Against Immune Complex-Induced Lung Injury", The Journal of Immunology, vol. 151, No. 10, Nov. 1993, pp. 5666-5674.
Handa et al, "Inhibition Of Infection With Human Immunodeficiency Virus Type 1 By Sulfated Gangliosides", Biochemical and Biophysical Research Communications, vol. 175, No. 1, Feb. 1991, pp. 1-9.
Bajorath, et al. Biochemistry (Feb. 1994), 33(6), 1332-9.
Miyasaka Masayuka
Suzuki Yasuo
Ward Peter A.
Conrad, III Joseph M.
Dees Jos,e G.
The Regents of the University of Michigan
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