Methods of administering and pharmaceutical formulations contain

Details Methods of administering and pharmaceutical formulations contain Methods of administering and pharmaceutical formulations contain

1994-03-25

1996-10-01

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 31165

Patent

active

055611613

ABSTRACT:
A method of administering N-substituted benzamides, and their acid addition salts, in particular metoclopramide and its acid addition salts, is disclosed wherein the metoclopramide or acid addition salt is injected intramuscularly in a formulation with a pH of about 5.5 to about 7.0 and at a concentration of at least about 50 mg/ml, to deliver a dose of one to 5 mg/kg.

REFERENCES:
Pinder, R. M. . . . , et al. "Metoclopramide: A Review . . . ," Drugs, vol. 12, pp. 81-131 (1976).
King, F. D., et al. "5HT.sub.3 Receptor Antagonists," Drugs of the Future, vol. 14, pp. 875-889 (1989).
Topart, J., et al. "Etude Spectroscopique de Quelques . . . ," J. Pharm. Belg., vol. 28, pp. 633-648 (1973) (with translation).
Topart, J., et al. "Etude Spectroscopique de . . . ," Pharm. Acta Helv., vol. 51, pp. 314-325 (1976) [English summary at p. 325].
Collin, S. "Etude Structural de Benzamidas Substitues . . . ," J. Pharm. Belg., vol. 46, pp. 55-66 (1991) (with translation).
Hanocq. M., et al. "Relations entre les constantes d'acidite . . . ," Analysis vol. 7, pp. 246-248 (1979) (with translation).
Hanocq, M., et al. "Determination des Constantes d'acidite . . . ," J. Pharm. Belg. vol. 28, pp. 649-662 (1973) [English summary at p. 649].
VanDamme, M., et al. "Misc en evidence de liens hydrogene intramoleculaires . . . ," Pharm. Acta Helv., vol. 53, pp. 279-287 (1978).
Anker, L., et al. "NMR Conformational Study of Aminoalkylbenzamides . . . ," Helv. Chim. Acta, vol. 67, pp. 706-716 (1984).
Van de Waterbeemd, H., et al. "Theoretical Conformational Studies . . . ," J. Med. Chem., vol. 26, pp. 203-207 (1983).
VanDamme, M., et al. "Specific Role of Solvents . . . ," Pharm. Acta Helv., vol. 59, pp. 235-40 (1984).
VanDamme, M., et al. "Etude Spectrale Infrarouge et Raman . . . ," Analyt. Letters, vol. 12 (B4), pp. 339-349 (1979) [English abstract at pp. 339-340].
Van deWaterbeemd, H., et al. "Molecular Electrostatic Potential of Orthopramides . . . ," J. Med. Chem., vol. 29, pp. 600-606 (1986).
Van deWaterbeemd, H., et al. "Similarities of pharmacolphoric pattern . . . ," J. Molec. Graphics, vol. 4, pp. 51-55 (1986).
Pannatier, A., et al., "A theoretical conformational study . . . ," J. Pharm. Pharmacol., vol. 33, pp. 145-149 (1981).
DePaulis, I., et al. "Synthesis, crystal structure and antidopaminergic properties . . . ," Eur. J. Med. Chem., vol. 20, pp. 273-276 (1985).
Cesario, M., et al. "Structure cristalline du metoclopramide . . . ," Eur. J. Med. Chem., vol. 16, pp. 13-17 (1981) [English summary at p. 17].

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