Methods of administering phenothiazines and/or acid addition sal

Details Methods of administering phenothiazines and/or acid addition sal Methods of administering phenothiazines and/or acid addition sal

1995-06-07

1996-10-01

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3154

Patent

active

055611290

ABSTRACT:
A method of administering phenothiazines and their acid addition salts. The phenothiazine or acid addition salt is injected intramuscularly in a formulation with a pH of about 5.5 to about 7.0 and at a concentration of at least about 50 mg/ml, to deliver a dose of one to 5 mg/kg. The drug is administered either in a formulation containing Na.sup.+ ions and at a pH adjusted to reduce extrapyramidal side effects or in a formulation essentially free of Na.sup.+ ions.

REFERENCES:
Hancoq, M., et al. "Determination des Constantes d'acidite . . . ," J. Pharm. Belg. vol. 28, pp. 649-662 (1973).
Pero et al., "Progress in identifying clinical relevance . . . " Biochimie, 77, pp. 385-393 (1995).
King, F. D., et al. "SHT, Receptor Antagonists, Drugs of the Future", vol. 14, pp. 875-889 (1989).
Van deWaterbeemd, H., et al. "Similarities of pharmacophoric pattern . . . ," J. Molec. Graphics, vol. 4, pp. 51-55 (1986).
Ammar et al., Pharmazie 30(6) pp. 368-369 (1975).

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