Process for preparation of N-tert.butyl-decahydro-2-[2(R)-hydrox

Details Process for preparation of N-tert.butyl-decahydro-2-[2(R)-hydrox Process for preparation of N-tert.butyl-decahydro-2-[2(R)-hydrox

1995-12-20

1997-06-24

Davis, Zinna Northington

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40102

Patent

active

056418868

ABSTRACT:
The invention relates to a process for the preparation of N-tert.butyl-decahydro-2-[2(R)-hydroxy-4-phenyl-3(S)-phthalimidobutyl]-(4a S,8aS)-isoquinoline-3(S)-carboxamide of the formula ##STR1## as well as novel intermediates. The compound of formula I is a valuable intermediate for pharmacologically active compounds. The compound of formula I can be converted into pharmacologically active compounds which are suitable for the treatment of viral infections, such as those caused by HIV and other retroviruses.

REFERENCES:
patent: 5196438 (1993-03-01), Martin et al.
patent: 5451678 (1995-09-01), Parkes et al.
Hassal et al. Heterocycles 7:119-122 (1977).
Hassall et al. J. Chem. Soc. Perkin Transactions I, pp. 155-166 (1984).
Ikarya et al. J. Chem. Soc. Chem. Commun. pp. 922-924 (1985).
Parkes et al. J. Org. Chem. vol. 59, pp. 3656-3664 (1994).
Sasai et al. Tetrahedron Letters, vol. 55, No. 33 pp. 6123-6126 (1994).
Gao et al. J of the American Chem. Society, 110, 1988, 7538-7539.
Lohray et al. Tetrahedron Lett. 30(20), 1989, 2623-2626.
Chem Abstracts, 114(21), 1991, Abstr. No. 206159q & J. Chemical Society 2, 1991, 95-97, Lohray et al.
Patent Abstr. of Japan, 011(069)(C-407) 1987 & JP-A-61 227578.

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