Methods for in vivo delivery of substantially water insoluble ph

Details Methods for in vivo delivery of substantially water insoluble ph Methods for in vivo delivery of substantially water insoluble ph

1995-03-29

1996-10-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424451, 424465, 424 91, 424 9341, A61K 914

Patent

active

055609333

ABSTRACT:
In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.

REFERENCES:
patent: 4718433 (1988-01-01), Feinstein
patent: 5344640 (1994-09-01), Deutsch et al.
patent: 5370901 (1994-12-01), Tournier et al.
patent: 5439686 (1995-08-01), Desai et al.

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