Method of reducing the period before the onset of sleep

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514923, A61K 31405

Patent

active

056418019

ABSTRACT:
Methods of inducing sleepiness and sleep in an individual by administering to that individual a single dose of melatonin sufficient to induce sleepiness and sleep in the individual.

REFERENCES:
patent: 4600723 (1986-07-01), Short et al.
patent: 4665086 (1987-05-01), Short et al.
patent: 4687763 (1987-08-01), Wurtman
patent: 5242941 (1993-09-01), Lewy et al.
patent: 5362745 (1994-11-01), Graziella
patent: 5449683 (1995-09-01), Wurtman
Bettie, C.G. et al., J. Clin. Endocrin. Metalbol., 74:108-117 (1992).
Lewy, A.J., et al., "Light Suppresses Melatonin Secretion in Humans", Science, 210:1267-1269 (1980).
Aldhous, M. et al., "Plasma Concentrations of Melatonin in Man Following Oral Absorption of Different Preparations," Br. J. Cln. Pharma., 19:517-521 (1985).
Waldhauser, F. et al., "Changes in Melatonin Secretion with Age and Pubescence," Proceedings of the First International Congress on Melatonin, pp. 179-191, Vienna, Austria (1985).
Sack, R.L. et al., "Melatonin Administration to Blind People: Phase Advances and Entrainment," J. of Biol. Rhythms, 6(3):249-261 (1991).
Palm, L. et al., "Correction of Non-24-Hour Sleep/Wake Cycle by Melatonin in a Blind Retarded Boy," Annals of Neurol., 29:336-339 (1991).
Arendt, J. et al., "Some Effects of Jet-Lag and Their Alleviation by Melatonin," Ergonomics, 30:1379-1393, 1987.
Skene, D. J. et al., "Melatonin, Jet-Lag and the Sleep-Wake Cycle," Sleep '88, ed. J. Horne, pp. 39-41, Gustav Fischer Verlag, New York (1989).
Morton, D.J. et al., "Effect of Oral Melatonin at Various Dose Levels on Blood Pressure of Normotensive Humans," Med. Sci. Res., 17:837 (1989).
Carman, J.S.. et al., "Negative Effects on Melatonin on Depression," Am. J. Psychiatry, 133:1181-1186 (1976).
Waldhauser, F. et al., Lancet, 340:933-936 (1992).
Cagnacci, A. et al., "Melatonin: a Major Regulator of the Circadian Rhythm of Core Temperature in Humans," J. Clin. Endocrin. Met., 75:447-452 (1992).
Wendel, O.T. et al., Experimentia, 15:1167-1168 (1990).
Waldheiser, F. et al., Neuroendocrinology, 46:125-130 (1987).
Lieberman, H.R. et al, "Mood, Performance, and Pain Sensitivity, Changes Induced by Food Constituents," J. Psychiat. Res., 17(2):135-145 (1982/83).
Nickelsen, T. et al., "Influence of Subchronic Intake of Melatonin at Various Times of the Day on Fatigue and Hormonal Levels: A Placebo-Controlled, Double-Blind Trail," J. Pineal Research, 6:325-334 (1989).
MacFarlane, J.G. et al., "The Effects of Exogenous Melatonin on the Total Sleep Time and Daytime Alertness of Chronic Insomniacs: A Preliminary Study," Biol. Pyschiatry, 30:371-376 (1991).
Arendt, J. et al., "The Effects of Chronic, Small Doses of Melatonin Given in the Late Afternoon on Fatigue in Man: A Preliminary Study," Neuroscience Letters, 45:317-321 (1984).
James, S.P. et al., "The Effect of Melatonin on Normal Sleep," Neurophychopharmacology, 1(1):41-44 (1987).
Vollrath, L. et al., "Sleep Induction by Intranasal Application of Melatonin," Adv. in Bioscience, 29:327-329 (1981).
Hamilton, M., "Hamilton Psychiatric Rating Scale for Depression," Br. J. Soc. Clin. Psychol., 6:278-296 (1967).
Rosenthal, N.E., et al. The Psychobiology of Bulimia, eds. Hudson, II and Pope, J.G. Jr., American Psychiatric Press, Wash. D.C., pp. 205-228 (1987).
Jones, D.M. et al., J. Appl. Psych., 64:627-634 (1979).
Smith, A.P. et al., Neuropsychobiology, 18:144-148 (1987).
Wilkinson, R.T., Progress in Clinical Psychology, eds. Reiss, B.F. and Abt, L.A., Grune & Stratton, NY, pp. 28-43 (1969).
Lieberman, H.R. et al., Am. J. Clin. Nutr., 44:772-778 (1985).
Wilkinson, A.T. et al., Behav. Res. Meth. Instrum., 7:441-446 (1975).
File, S.E. et al., J. Clin. Psychopharmacol., 2:102-106 (1982).
McNair, P.M. et al., Profile of Mood States Manual, Educational and Industrial Testing Service, San Diego, CA (1971).
Hoddes, E. et al., "Quantification of Sleepiness: A New Approach," Psycho. Meth., 10:431-436 (1973).
Lerner, A.B. et al., Frontier of Pineal Physiology, MIT Press (1975) pp. 42-43.
Dawson, D. et al., "Melatonin and Sleep in Humans," J. Pineal Res., 15:1-12 (1993).
Lewy, A.J., et al., "The Use of Plasma Melatonin Levels and Light in the Assessment and Treatment of Chronobiologic Sleep and Mood Disorders," J. Neural. Transm., 21:311-322 (1986).
Borbely, A.A., "Endogenous Sleep-Substances and Sleep Regulation," J. Neural. Transm., 21:243-254 (1986).
Touitou, Y. et al., "Melatonin and the Pineal Gland," Proceedings of the International Symposium on Melatonin and the Pineal Gland: From Basic Science to Clinical Application, pp. 235-239 (Sep. 6-9, 1992).
Lisoni, P. et al., "Effect of an Acute Injection of Melatonin on the Basal Secretion Hypophyseal Hormones in Prepubertal and Pubertal Healthy Subjects," Acta Endocrinologica, 111:305-311 (1986).
Cassone, V.M. et al., "Dose Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin," J. of Biol. Rhythms, 1(3):219-229 (1986).
James, S.P. et al., "Melatonin Administration in Insomnia," Neuropsych., 3(1):19-23 (1990).
Hoechst, A.G., "Melatonin Based Nasal Spray Compsn. for Use of Sleep Inducer--Prep by Dissolving Melatonin, i.e. 5-methoxy-N-acetyl Tryptamine in Aq Doln. Contg. Sodium Chloride," Derwent Publications, Ltd., London, GB, Week 8040, 29 Apr. 1980 (Abstract No. JP55057563).
Johnson, L.C. and Chernik, D.A., "Sedative-Hypnotics and Human Performance," Psychopharm., 76:101-113 (1982).
Johanson, C.E., and Uhlenhuth, E.H., "Drug Preference and Mood in Humans: Diazepam," Psychopharm. 71:269-273 (1980).
Lewy, A.J., et al., "Immediate and Delayed Effects of Bright Light on Human Melatonin Production: Shifting Dawn and Dusk Shifts the Dim Light Melatonin Onset (DLMO).sup.a," In Wurtman, R.J., et al., The Medical and Biological Effects of Light, Annals of the New York Acad. of Sci., vol. 453 (1985).
Arendt, J. et al., "Some Effects of Melatonin and the Control of its Secretion in Humans," Photoperiodism, Melatonin and the Pineal, CIBA Foundation Symposium, 117:266-283 (1985).
Folkard, S. et al., "Melatonin stabilizes sleep onset time in a blind man without entrainment of cortisol or temperature rhythms," Neuroscience Letters, 113:193-198 (1990).
Dahlitz, M. et al., "Delayed Sleep Phase Syndrome Response to Melatonin," The Lancet, 337:1121-1124 (1991).
Ouichou, A. et al., "Delta-Sleep Inducing Peptide Stimulates Melatonin, 5-Methoxtryptophol and Serotonin Secretion from Perifused Rat Pineal Glands," Biol. Signals, 1:65-77 (1992).
Lieberman, H.R. and Lea, A.E., "Melatonin: Effects on Sleep and Behavior in Man," Melatonin Clinical Perspectives, Oxford University Press, pp. 119-127 (1988).
Waldhauser, F. et al., "Sleep Laboratory Investigations on Hypnotic Properties of Melatonin," Psychopharmacology, 100:222-226 (1990).
Wurtman, R.J. and Waldhauser, F. et al., "Melatonin in Humans," Proc. of the First International Congress on Melatonin, Nov. 7-9, pp. 179-191, Vienna, Austria (1985).
Lewy, A.J., et al., "A Complete PRC for Melatonin Administration in Humans," Abst. vol. 3, Society for Light Treatment and Biological Rhythms, p. 26 (1991).
Dollins, A.B. et al., "Effects on Ambient Illumination on Human Nocturnal Serum Melatonin Levels and on Sustained Performance," Abst., vol. 3 Society for Light Treatment and Biological Rhythms, p. 25 (1991).
Lieberman, H.R. et al., "Effects of Melatonin on Human Mood and Performance," Brain Research, 323:201-207 (1984).
Reiter, R.J., "Melatonin: the Chemical Expression of Darkness," Mol. and Cell. Endoc., 79:C153-C158 (1991).
Voordouw, B.C.G., et al., "Melatonin and Melatonin-Progestin Combinations Alter Pituitary-Ovarian Function in Women and Can Inhibit Ovulation," J. of Clinical Endoc. and Metab., 74(1):108-117 (1992).
Anton-Tay, F., "Melatonin: Effects on Brain Function," Adv. Biochem Psychopharm., 11:315-324 (1974).
Anton-Tay, F. et al., "On the Effect of Melatonin Upon Human Brain: Its Possible Therapeutic Implications," Life Sciences, 10:841-850, Part I (1971).
Strassman, R.J. et al., "Elevated Rectal Temperature produced by All-Night Bright Light is Reversed by Melatonin Infusion in Men," J. Appl. Physiol., 71(6):2178-2182 (1991).
Paccot

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of reducing the period before the onset of sleep does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of reducing the period before the onset of sleep, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of reducing the period before the onset of sleep will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-149524

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.