Certain 3-[3-(3-pyridinyloxy)propoxy or propylthio]-acetic acid

Details Certain 3-[3-(3-pyridinyloxy)propoxy or propylthio]-acetic acid Certain 3-[3-(3-pyridinyloxy)propoxy or propylthio]-acetic acid

1987-10-16

1988-12-06

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546300, 546334, 546341, 546344, C07D21365

Patent

active

047897457

ABSTRACT:
The present invention provides novel .omega.-(3-pyridynl) oxa-, thia-, and aza- alkanoic acids and esters thereof, which are useful as thromboxane A.sub.2 (TXA.sub.2) inhibitors and as such represent potent pharmacological agents.

REFERENCES:
patent: 2559546 (1951-07-01), Perkins
patent: 4112224 (1978-09-01), Bundy
D. Harris, et al., Advances in Prostaglandin and Thromboxane Research 6:437 (1980).
T. Miyamoto, et al., Advances in Prostaglandin and Thromboxane Research 6:443 (1980).
H. Tai, et al., Advances in Prostaglandin and Thromboxane Research 7:447 (1980).
Leardini, et al., Synthesis 3:225 (1982).
Kamiya, Chem. Pharm. Bull. 23:2744 (1975).
Rovier, et al., Bull. Soc. Chim. Fr. 5:1717, 1718 (1971).
Chem. Abstracts, Tenth Collective Index, Chem. Substances 3H-Pyrazole-Questran, p. 46, 178CS (1981).
Tanouchi et al., Chem. Abstracts, vol. 95 (15), Abst. No. 95:125,868g, Oct. 12, 1981.

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