Oligonucleotide derivatives and production thereof

Details Oligonucleotide derivatives and production thereof Oligonucleotide derivatives and production thereof

1987-02-20

1988-12-06

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2104

Patent

active

047897376

ABSTRACT:
An oligonucleotide derivative having an amino group protected with an eliminatable group bonded through a phosphate group and a spacer with an appropriate length to the 5'-end of an oligonucleotide protected suitably at the 3'-hydroxyl group and the base moiety of the nucleotide, and an immobilized oligonucleotide derivative having a Sepharose carrier bonded to the amino group in place of said protective group are disclosed. Methods for production of these derivatives are also disclosed.

REFERENCES:
patent: 4667025 (1987-05-01), Miyoshi et al.
Tetrahedron Letters, pp. 3635-3638 (1979).
J. Am. Chem. Soc., 103, 706-708 (1981).
Tetrahedron, 34, pp. 3143-3178 (1978).
Nucleic Acid Res., vol. 8, No. 22, pp. 5491-5505, 5507-5517, (1980).

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