Memory enhancing .alpha.-alkyl-4-amino-3-quinolinemethanols and

Details Memory enhancing .alpha.-alkyl-4-amino-3-quinolinemethanols and Memory enhancing .alpha.-alkyl-4-amino-3-quinolinemethanols and

1986-08-25

1988-12-06

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546159, 558414, C07D21514, A61K 3147

Patent

active

047896787

ABSTRACT:
There are described compounds of the formula ##STR1## where X is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; R is ##STR2## R.sub.4 being loweralkyl; R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; R.sub.2 is hydrogen, loweralkyl or arylloweralkyl; and R.sub.3 is loweralkyl, with the proviso that when R is acetyl, R.sub.3 is methyl and X is hydrogen, R.sub.1 and R.sub.2 are not both hydrogen, or pharmaceutically acceptable acid addition salts thereof, which are useful in the treatment of various memory dysfunctions characterized by decreased cholinergic function.

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patent: 4631286 (1986-12-01), Shutske et al.
patent: 4695573 (1987-09-01), Shutske et al.
Abstract for Japan Patent 43-20294 (8/31/68).
"A Survey of Antimalarial Drugs" (1941-1945), Frederick Y. Wiselogle (Editor), vol. II, Part 2, pp. 1047, etc. (1946).
Schafer et al., J. Prakt. Chem., 321, pp. 695-698 (and English translation, pp. 1-5) (1979).
Hershenson et al., J. Med. Chem., 29, pp. 1125-1130 (1986).
Davies, Drug Development Research, 5, pp. 69-76 (1985).

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