Process for the preparation of 2-aminoalkane-1,3-diols

Details Process for the preparation of 2-aminoalkane-1,3-diols Process for the preparation of 2-aminoalkane-1,3-diols

1995-11-29

1997-07-15

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564224, 564258, 564489, C07C20940

Patent

active

056485441

ABSTRACT:
A process for the preparation of 2-aminoalkane-1,3-diols by a single step reduction of alkyl 2-oximino-3-oxoalkanoates. The reduction is carried out in the presence of at least one hydride, in a solvent, under inert atmosphere and at a controlled initial temperature.
Synthetic yields are markedly improved.

REFERENCES:
patent: 5012000 (1991-04-01), Illig et al.
patent: 5488167 (1996-01-01), Hudlicky
Gregory and Malkin, Jounal of the Chemical Society, 1951 pp. 2453-2456.
Hayes and Gever, Journal of Organic Chemistry, vol. 16, 1951 pp. 269-278.
Fisher, Chemistry and Industry, 1952 pp. 130-131.
Adkins and Billica, Journal of the American Chemical Society, vol. 71, 1948, pp. 3121-3125.

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