Process for synthesizing carbapenem side chain intermediates

Details Process for synthesizing carbapenem side chain intermediates Process for synthesizing carbapenem side chain intermediates

1996-07-22

1997-07-15

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49508

Patent

active

056485018

ABSTRACT:
A process of synthesizing a compound of the formula I: ##STR1## is described. A compound of the formula II: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula IV: ##STR3## Compound IV is then reacted with Na.sub.2 S in water to produce a compound of formula I.

REFERENCES:
patent: 5322952 (1994-06-01), Sunagawa et al.
Heterocycles, vol. 41, pp. 147-159 (1995), by Matsumura, et al.
CA 119: 271142w Preparation of . . . intermediates. Sunagawa et al. p. 996 1993.
CA 122: 239477k An efficient . . . derivatives. Matsumura et al. p. 1038 1995.

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