Antimycobacterial compounds and method of using same

Details Antimycobacterial compounds and method of using same Antimycobacterial compounds and method of using same

1995-02-07

1997-07-15

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514924, A61K 3120

Patent

active

056483929

ABSTRACT:
The present invention provides a compound having the structure: ##STR1## wherein R is a branched or unbranched C1-C30 alkyl or alkenyl; or a branched or unbranched C1-C30 alkyl or alkenyl substituted with S, O, N, P, SO.sub.2, F, C1, Br, or I, wherein S, O, N, P, or SO.sub.2 replaces at least one --CH.sub.2 --, and F, Cl, Br, or I replaces at least one H. The present invention also provides a pharmaceutical composition comprising the compound above, as well as a method for treating a mycobacterial disease or infection in a subject in need of such treatment by administering to the subject an effective amount of the compound above.

REFERENCES:
Merck Manual, 1987. p. 126.
CA 68:112393, 1968.
"Inactivation of General Acyl-CoA Dehydrogenase from Pig Kidney by 2-Alkynoyl Coenzyme A Derivatives: Initial Aspects" by Freund, et al. Biochemistry 1985, 24, pp. 5996-6002.

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