Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-01-19
1997-07-15
Naff, David M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
435125, 435126, 514461, 514468, 549414, 549433, A61K 3135, A61K 3134, C12P 1706, C07D40700
Patent
active
056483767
ABSTRACT:
An immunosuppressant compound is produced having the structure: ##STR1## or a mirror image thereof, wherein X.sub.1 is 2,2-dimethylvinyl and X.sub.2 and X.sub.3 together are .dbd.CH.sub.2 ; or X.sub.1 is 2,2-dimethyloxiranyl, and X.sub.2 and X.sub.3 together are --0--CH.sub.2 --; or X.sub.1 is 1,2-dihydroxy-2-methyl-propyl, X.sub.2 is --CH.sub.2 OH, and X.sub.3 is OH; or X.sub.1 is 2-hydroxy-2-methylpropyl, X.sub.2 is H, and X.sub.3 is CH.sub.2 OH; or X.sub.1 is COOR, and X.sub.2 and X.sub.3 together are .dbd.O, where R is a lower alkyl, phenyl, or benzyl group; or X.sub.1 is 2-methylpropyl, X.sub.2 is H, and X.sub.3 is CH.sub.3. The compound can be produced by culturing Fusarium subglutinans f. sp. tripterygii ATCC 74358 isolated from the stems of Tripterygium wilfordii. A pharmaceutical composition for immunosuppression therapy is prepared containing the compound and a pharmaceutically acceptable vehicle.
REFERENCES:
patent: 5294443 (1994-03-01), Lipsky et al.
patent: 5430054 (1995-07-01), Qian et al.
Zheng, et al., Zhongguo Xixue Kexueyuan Xuebao (1994), 16(1), 24-8.
Zheng, et al., Zhongguo Xixue Kexueyuan Xuebao (1991), 13(6), 391-7.
Pliam Nathan B.
Strobel Gary A.
Dehlinger Peter J.
Gorthey LeeAnn
Naff David M.
Pharmagenesis, Inc.
Powers Vincent M.
LandOfFree
Immunosuppressant diterpene compound does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immunosuppressant diterpene compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunosuppressant diterpene compound will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1492603