Tumor necrosis factor production inhibitors

Details Tumor necrosis factor production inhibitors Tumor necrosis factor production inhibitors

1994-12-28

1997-07-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514281, 546 39, 546 44, 546 45, A61K 3144, A61K 31445, C07D491153, C07D49118

Patent

active

056483597

ABSTRACT:
There is provided a composition for inhibiting the production or secretion of tumor necrosis factor effective for the treatment of cachexia, septic shock, multiple organ failure, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, osteoarthritis, Behcet disease, systemic lupus erythematosus (SLE), graft versus host disease (GvHD), malaria, acquired immune deficiency syndrome (AIDS), meningitis, hepatitis and Type II diabetes mellitus. The composition comprises a pharmaceutically effective amount of a compound of formula (1).

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