Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Details Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines

1979-07-30

1981-10-20

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21168

Patent

active

042962390

ABSTRACT:
6-Amino-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.3 -alkyl, R.sub.1 is hydrogen or halogen, and the two R.sub.2 groups are taken together with the nitrogen to which they are bonded to complete a nitrogen ring moiety selected from the group consisting of pyrrolidino, piperidino, morpholino and 3,6-dihydro-1(2H)-pyridyl, and the pharmacologically acceptable salts thereof, are central nervous system depressant drugs which are useful in effective dosages in domestic and zoo animals for their calming and tranquilizing uses during shipment and to reduce aggressive behavior. In man these compounds are potentially useful for controlling anxiety and schizophrenia and for their sedative, muscle relaxant and anti-convulsant activity.

REFERENCES:
patent: 4009175 (1977-02-01), Hester, Jr.
patent: 4044129 (1977-08-01), Kuwada et al.
patent: 4180668 (1979-12-01), Hester, Jr.
Hester, Jr., Tetrahedron Letters, No. 20, pp. 1609-1612, (1971).

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