Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-12-08
1997-06-24
Rories, Charles C. P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 6, 435375, 536 245, 536 235, 536 243, 536 2431, 536 2433, A61K 3170, C07H 2100, C12N 510, C12Q 168
Patent
active
056417560
ABSTRACT:
Disclosed are oligonucleotides complementary to VEGF-specific nucleic acid useful in reducing the expression of VEGF. Also disclosed are pharmaceutical formulations containing such oligonucleotides useful for treating various disorders associated with neovascularization and angiogenesis.
REFERENCES:
Nomura et al. (1995) The Journal Of Biological Chemistry 270:28316-28324.
Monacci et al. (1993) American Journal Of Physiology 264:c995-c1002.
Garrido et al. (1993) Growth Factors 8:109-117.
Uhlmann et al. (1990) Chemical Reviews 90:543-584.
Pierce et al. (1995) Investigative Ophthalmology & Visual Science 36:Abstract 3990.
Smith et al. (1995) Investigative Ophthalmology & Visual Science 36:Abstract 3992.
Michaelson (1948) Trans. Ophthalmol. Soc. U.K. 68:137-180.
Ashton et al. (1954) Br. J. Ophthalmol. 38:397-432.
Am J. Ophthalmol. (1976) 81:383-396.
Knighton et al. (1983) Science 221:1283-1285.
Senger et al. (1986) Cancer Res. 46:5629-5632.
Folkman et al. (1987) Science 235:442-446.
Ophthalmol. (1991) 18:741-840 (Supplement).
Klagsbrun et al. (1991) Ann. Rev. Physiol. 53:217-239.
Tischer et al. (1991) J. Biol. Chem. 266:11947-11954.
Claffey et al. (1992) J. Biol. Chem. 267:16317-16322.
Plate et al. (1992) Nature 359:845-848.
Plouet et al. (1992) Invest. Ophthalmol. Vis Sci.34:900.
Schweiki et al. (1992) Nature 359:843-845.
Adamis et al. (1993) Biochem. Biophys. Res. Commun. 193:631-638.
Adamis et al. (1993)Invest. Ophthalmol. Vis. Sci. 34:1440.
Kim et al. (1993) Nature 362:841-844.
Miller et al. (1993) Principles and Practice of Ophthalmology, W.B. Saunders, Philadelphia, pp. 760.
Aiello et al. (1994) New Eng. J. Med. 331:1480-1487.
Aiello et al. (1994) Invest. Ophthalmol. Vis. Sci. 35:1868.
Bressler et al. Principles and Practices of Opthalmology (eds. Albert and Jakobiac), W.B. Saunders Co., Philadelphia, PA) (1994) vol. 2 pp. 834-852.
Foster in Harrison's Principles of Internal Medicine (Isselbacher et al., eds.) McGraw-Hill, Inc., New York (1994) pp. 1994-1995.
Pierce et al. (1994) Int. Ophth. Clinics 34:121-148.
Simorre-Pinatel et al. (1994) Invest Ophthalmol. Vis. Sci. 35:3393-3400.
Smith et al. (1994) Invest. Ophthalmol. Vis. Sci. 35:1442.
Smith et al. (1994) Invest. Ophthalmol. Vis. Sci. 35:101-111.
Focus (Jan. 6, 1995).
Ophthalmology World News (1995) p. 26.
Ophthalmology Times (Jan. 16-22, 1995).
Pierce et al. (1995) Proc. Natl. Acad. Sci. (USA) 92:905-909.
Uchida et al., (1995) Antisense Res. & Dev. 5(1):87 (Abstract OP-10).
Nomura et al., (1995) Antisense Res. & Dev. 5(1):91 (Abstract OP-18).
Hybridon, Inc.
Rories Charles C. P.
LandOfFree
Modified VEGF oligonucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified VEGF oligonucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified VEGF oligonucleotides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-149191