Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-06-18
1997-07-15
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435348, 435325, 435419, 4352523, 4352542, 536235, C12N 1500, C12N 1512, C12N 1563, C12N 1585
Patent
active
056482388
ABSTRACT:
The present invention provides a polynucleotide (ipkc) which identifies and encodes a novel human protein kinase C inhibitor homolog (IPKC). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKC.
REFERENCES:
Hillier L, et al., Unpublished, Database EST, Accession No. R28145 Apr. 25, 1995.
Pearson JD, et al., "Amino acid sequence and characterization of a protein inhibitor of Protein Kinase C." JBC 265 (8): 4583-4591 Mar. 15, 1990.
Mozier NM, et al. "Characterization of a novel zinc binding site of protein kinase C inhibitor-1." FEBS 279: 14-18 Feb. 1991.
Simpson et al., "Isolation of a maize cDNA encoding a protein with extensive similarity to an inhibitor of protein kinase C and a cyanobacterial open reading frame," Biochem. Biophys. Acta., 1222:306-308 (1994).
Waller et al. (Direct Submission), GenBank Sequence Database (Accession U09405), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Brzoska et al., "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor," Proc. Natl. Acad. Sci. USA, 92:7824-7828 (Aug. 1995).
Grunicke et al., "Role of protein kinases in antitumor drug resistance," Ann. Hematol, 69:S1-6 (1994).
O'Brian et al., "The Tumor Promoter Receptor Protein Kinase C: A Novel Target for Chemoprevention and Therapy of Human Colon Cancer," Prog. Clin. Biol. Res., 391:117-120.
O'Brien et al., "Biology of the protein kinase C family" Cancer Metastasis Rev., 8:199-214 (1989).
Kolch et al., "Protein kinase C.alpha. activates RAF-1 by direct phosphorylation" Nature, 364:249-252 (Jul. 15, 1993).
Yamanishi et al., "Alterations In Gene Expression and Signal Transductions in Human Melanocytes and Melanoma Cells," Crit. Rev. Oncog., 5(5):429-450 (1994).
Olds et al., "Roles of PKC," New Biol., 3(1):27-35 (Jan. 1991).
Saito et al., ".alpha.-. .beta.II- and .gamma.-subspecies of protein kinase C localized in the monkey hippocampus: pre- and post-synaptic localization of .gamma.-subspecies," Brain Res., 656:245-256 (1994).
Abeliovich et al., "Modified Hippocampal Long-Term Potentiation in PKC.gamma.-Mutant Mice," Cell Press, 75:1263-1271 (Dec. 31, 1993).
Lucas et al., "Protein Kinase C Involvement in Apoptosis," Gen. Pharmacol., 26(5):881-887 (1995).
Chen et al., "Phosphorylation of Bc1-2 Portein and Association with p21.sup.Ras in Ras-induced Apoptosis," J. Biol. Chem., 271(5):2376-2379 (Feb. 2, 1996).
Ohkusu et al., "Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL-1pr/1pr mice," Eur. J. Immunol. 25:3180-3186 (1995).
Zong et al., "Saikosaponin b.sub.2 -Induced Apoptosis of Cultured B16 Melanoma Cell Line through Down-regulation of PKC Activity," Biochem. Biophys. Res. Commun., 219(0259):480-485, (1996).
Emoto et al., "Proteolytic activation of protein kinase C .delta. by an ICE-like protease in apoptotic cells," EMBO. J., 14(24):6148-5156 (1995).
Mori et al., "Inhibitory Action of Chlorpromazine, Dibucaine, and Other Phospholipid-interacting Drugs on Calcium-activated, Phospholipid-dependent Protein Kinase," J. Biol. Chem., 255(18):8378-8380 (Sep. 25, 1980).
Schatzman et al., "Phospholipid-Sensitive Calcium-Dependent Protein Kinase: Inhibition by Anti-Psychotic Drugs" Biochem. Biophys. Res. Commun., 98(3):669-676 (Feb. 12, 1981).
O'Brien et al., "Inhibition of Protein Kinase C by Tamoxifen.sup.1 " Cancer Res., 45:2462-2465 (Jun. 1985).
Hannun et al., "Aminoacridines, Potent Inhibitors of Protein Kinase C," J. Biol. Chem., 263(11):5124-5131.
Hidaka et al., "Isoquinolinesulfonamides, Novel and Potent Inhibitors of Cyclic Nucleotide Dependent Protein Kinase and Protein Kinase C," Biochemistry, 23:5036-5141 (1984).
House et al., "Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain," Science, 238:1726-1728 (1987).
Ward et al., "Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein" Cancer Letters, 88:37-40 (1995).
Behrens et al., "Apoptosis Induced by Protein Kinase C Inhibition in a Neuroblastoma Cell Line.sup.1,2," Cell Growth 6:1375-1380 (1995).
Zhang et al., "Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C," Cancer Letters, 96:31-35 (1995).
Levitzki, A., "Signal-transduction therapy, A novel approach to disease management," Eur. J. Biochem., 226:1-13 (1994).
Au-Young Janice
Hawkins Phillip R.
Hillman Jennifer L.
Billings Lucy J.
Elliott George C.
Incyte Pharmaceuticals Inc.
Nelson Amy J.
LandOfFree
Human protein kinase C inhibitor homolog does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human protein kinase C inhibitor homolog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human protein kinase C inhibitor homolog will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1491747