Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-10-17
1997-07-15
Hulina, Amy
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
12866001, 424491, 424493, A61K 950, A61B 800
Patent
active
056480989
ABSTRACT:
The foregoing invention relates to a new microbubble preparation and thrombolytic therapy which relies on microbubbles and ultrasound for its lytic activity. The pharmaceutical composition of the invention comprises a liquid solution of microbubbles with an internal atmosphere enhanced with the perfluorocarbon gas which cavitate in the presence of an ultrasound field following intravenous injection or infusion of said composition into said host. For thrombolysis the area of a thrombus is exposed to an ultrasound field in the presence of the microbubbles and significant lysis is experienced. The method and pharmaceutical composition of the invention exhibit thrombolytic properties similar to those of other thrombolytic agents such as urokinase and are less toxic and are clot specific in that they do not introduce a systemic lytic state to a said animal.
REFERENCES:
patent: 5040537 (1991-08-01), Katakura
patent: 5310540 (1994-05-01), Giddey et al.
patent: 5315998 (1994-05-01), Tachibana et al.
patent: 5385725 (1995-01-01), Lin et al.
patent: 5393524 (1995-02-01), Quay
patent: 5409688 (1995-04-01), Quay
patent: 5413774 (1995-05-01), Schneider et al.
Hulina Amy
The Board of Regents of the University of Nebraska
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