Mitomycin analogs

Details Mitomycin analogs Mitomycin analogs

1979-12-05

1981-05-19

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

26032624, 548214, 424263, 424270, 424274, 546271, C07D48714

Patent

active

042686768

ABSTRACT:
Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R.sup.1, and R.sup.2 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.3 is selected from the group consisting of lower alkenyl, halo-lower alkenyl, lower alkynyl, lower akloxycarbonyl, thienyl, formamyl, tetrahydrofuryl and benzene sulfonamide.
Also disclosed are novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula, Ia, ##STR3## wherein: Y is hydrogen or lower alkyl; and Z is a thiazolamino radical, a furfurylamino radical, a cyclpropylamino radical, a pyridylamino radical, or a radical of the formula, ##STR4## in which R.sup.4, R .sup.5, and R.sup.6 are the same or different and selected from the group consisting of hydrogen and lower alkyl, and R.sup.7 is selected from the group consisting of lower alkenyl, halo-lower alkenyl, lower alkynyl, lower alkoxycarbonyl, halo-lower alkyl, hydroxy-lower alkyl, pyridyl, thienyl, formamyl, tetrahydrofuryl, benzyl, and benzene sulfonamide.

REFERENCES:
patent: 3332944 (1967-07-01), Cosulich et al.
patent: 3450705 (1969-06-01), Matsui et al.
patent: 3514452 (1964-06-01), Matsui et al.
Kinoshita et al.; J. Med. Chem., vol. 14, pp. 103-112 (1971).
Usubuchi et al.; GANN, vol. 58, pp. 307-313 (1967).
Oboshi et al.; GANN, vol. 58, pp. 315-321 (1976).
Matsui et al.; J. Antibiotics, vol. XXI, pp. 185-198 (1968) .
Cheng et al.; J. Med. Chem., vol. 20, pp. 767-770 (1977).

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