Method of treating tumors

Details Method of treating tumors Method of treating tumors

1995-03-24

1997-07-15

Kight, John

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

A61K 3174

Patent

active

056480717

ABSTRACT:
In accordance with the present invention, a method is provided for treating tumors. More particularly, the present invention relates to a method for treating tumors comprising injecting a solution of certain ethylene oxide-propylene oxide surface-active copolymers and a solution containing chemotherapeutic agents into a human or animal with a tumor. The solutions can be injected simultaneously or separately at different times. In addition, the surface-active copolymer and the chemotherapeutic agent can be in the same solution. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula:

REFERENCES:
patent: Re29909 (1979-02-01), Kurtz
patent: 2674619 (1954-04-01), Lundsted
patent: 2854378 (1958-09-01), Buckwalter et al.
patent: 2979528 (1961-04-01), Lundsted
patent: 3036118 (1962-05-01), Jackson
patent: 3089818 (1963-05-01), Stone
patent: 3140232 (1964-07-01), Noseworthy
patent: 3228834 (1966-01-01), Gans
patent: 3450502 (1969-06-01), Hymes
patent: 3577522 (1971-05-01), Hymes
patent: 3590125 (1971-06-01), Hymes
patent: 3641240 (1972-02-01), Hymes et al.
patent: 3740421 (1973-06-01), Schmolka
patent: 3867521 (1975-02-01), Miskel et al.
patent: 3867533 (1975-02-01), Schmolka
patent: 3956259 (1976-05-01), Garcia et al.
patent: 3980772 (1976-09-01), Ginger et al.
patent: 4073886 (1978-02-01), Kehm
patent: 4100271 (1978-07-01), Krezanoski
patent: 4179337 (1979-12-01), Davis et al.
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4305922 (1981-12-01), Rhodes
patent: 4378347 (1983-03-01), Franco
patent: 4395393 (1983-07-01), Schmolka
patent: 4407790 (1983-10-01), Oakes et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4606918 (1986-08-01), Allison et al.
patent: 4609546 (1986-09-01), Hiratani
patent: 4801452 (1989-01-01), Hunter et al.
patent: 4837014 (1989-06-01), Hunter et al.
patent: 4837083 (1989-06-01), Hunter et al.
patent: 4879109 (1989-11-01), Hunter
patent: 4897263 (1990-01-01), Hunter
patent: 4937070 (1990-06-01), Hunter
patent: 4997644 (1991-03-01), Hunter
patent: 5017370 (1991-05-01), Hunter et al.
patent: 5028599 (1991-07-01), Hunter
patent: 5030448 (1991-07-01), Hunter
patent: 5032394 (1991-07-01), Hunter
patent: 5039520 (1991-08-01), Hunter
patent: 5041288 (1991-08-01), Hunter
patent: 5047236 (1991-09-01), Hunter et al.
patent: 5064643 (1991-11-01), Hunter et al.
patent: 5071649 (1991-12-01), Hunter
patent: 5078995 (1992-01-01), Hunter et al.
patent: 5080894 (1992-01-01), Hunter et al.
patent: 5089260 (1992-02-01), Hunter et al.
patent: 5250294 (1993-10-01), Hunter et al.
Schmolka, I., "A Review of Block Polymer Surfactants", Journal of American Oil Chemists Society, 54, No. 3, pp. 110-116 (1977).
Rodeheaver, G.T., "Pluronic.RTM. F-68: A Promising New Skin Wound Cleanser", Ann Emerg Med, 9:11, pp. 572-576 (1980).
Moore, A.R., et al., "Reduction of Splenic Vascular Resistance During Profusion by Pluronic.RTM. F-68", Journal of Surgical Research, Vo.. 8, pp. 563-566 (1968).
Brenner, K.U., et al., "Cold-Induced Platelet Aggregation In Vivo And Its Inhibition By A Nonionic Surface Active Substance", Thrombosis Research, vol. 2, pp. 331-342 (1973).
Hymes, A.C., et al., "The Influence Of An Industrial Surfactant Pluronic.RTM. F-68, In The Treatment of Hemorrhagic Shock", Journal of Surgical Research, vol. 11, pp. 191-197 (1971).
Hoie, J., et al., "Effects of Pluronic.RTM. F-68, Poloralkol, On Vascular Resistance in Vivo", Journal of Surgical Research, vol. 11, pp. 515-517 (1971).
Grover, F.L., et al., "A nonionic Surfactant And Blood Viscosity", Arch. Surg., vol. 106, pp. 307-310 (1973).
Grover, F.L., et al., "The Effect of Pluronic.RTM. F-68 On Circulatory Dynamics And Renal and Carotid Artery Flow During Hemorrhagic Shock", Journal of Surgical Research, vol. 17, pp. 30-35 (1974).
Ketchum, L.D., et al., "Experimental Use of Pluronic.RTM. F-68 In Microvascular Surgery", Plastic and Reconstructive Surgery, vol. 53, pp. 288-292 (1974).
Ketchum, L. D., "Experimental Use of Pluronic F-68 in Microvascular Surgery", Plastic Reconstructive Surgery, vol. 54, p. 478 (Oct. 1974).
Richard, M.N., et al., "Effect of Lysine and Wettig Agents on Activated Plasinogen Solutions", Canadian Journal of Biochemistry & Physiology, vol. 41, pp. 211-217 (1963).
Block and Graft Copolymerization, vol. 2, (ed. by R. J. Ceresa, John Wiley & Sons, 1976), "The Applications of Block Copolymer Polyol Surfactants", L. G. Lundsted and I. R. Schmolka; pp. 174-205 and pp. 255-272 (references).
Reindorf, C.A., et al., "Perfluorocarbon Compounds: Effects on the Rheological Properties of Sickle Erythrocytes in vitro", American Journal of Hematology, vol. 19, pp. 229-236 (1985).
Padilla, F., et al., "Effect of Fluorocarbon Emulsions on the Mechanical Fragility of Normal and Sickle Cells: In Vitro Studies" Federation Proceedings, vol. 34, pp.1510-1512 (1975).
Vercellotti, G. M., et al., "Activation of Plasma Complement by Perfluorocarbon Artificial Blood: Probable Mechanism of Adverse Pulmonary Reactions in Treated Patients and Rationale for Corticosteroid Prophylaxis", Blood, vol. 59, pp.1299-1304 (1982).
Janoff, A. S., et al.,"The Modification of Human Erythrocyte Membrane Structure by Membrane Stabilizers: An Electron Spin Resonance Study", American Journal of Hematology, vol. 10, pp. 171-179 (1981).
Ketchum, L. D., "Pharmacological Alterations in the Clotting Mechanism: Use in Microvascular Surgery", Journal of Hand Surgery, vol. 3, pp. 407-415 (1978).
Vasko, K. A., et al., "Poloxalkol.RTM. (Pluronic F-68): A Priming Solution for Cardiopulmonary Bypass", Trans. Am. Soc. Artif. Int. Organs, 18, 526-531 (1972).
Block, N. L., et al., "Acutely Traumatized Canine Ureter: Effects of Low Molecular Weight Dextran and Surfactant Pluronic F-68", Urology, vol. III 190-194 (1974).
Knize, D. M., et al., "Use of Antisludging Agents in Experimental Cold Injuries", Surgery, Gynecology & Obstetrics, vol. 129, pp. 1019-1026 (1969).
Organ Perfusion and Preservation, (ed. by Norman, J. C., Appleton-Century-Crofts,) 1968), Paton, B. C., et al., "The Use of a Nonionic Detergent Added to Organ Perfusates", pp. 105-120.
Smillie, J. A., et al., "Cryopreservation of Human Platelets with Polyvinylpyrrolidone", Transfusion, vol. 21, pp. 552-556 (1981).
Gaehtgens, P., et al., "Disaggregation of Human Red Blood Cells by Various Surface-Active Agents as Related to Changes of Cell Shape and Hemolysis", Act Heamat., vol. 33, pp. 82-89 (1975).
Advances in Blood Substitute Research (ed. by Bolin, et al., Alan R. Liss, Inc. New York (1983) Sugi, et al., The Use of Fluosol-DA (FDA) in Emergency Situations: A report of 67 clinical cases, Abstract/451.
Lane, T. A., et al., "Reduction in the Toxicity of a Component of an Artificial Blood Substitute by Supercritical Fluid Fractionation", Transfusion, vol. 28, pp. 375-378 (1987).
Lane, T. A., et al., "Paralysis of Phagocyte Migration Due to an Artificial Blood Substitute", Blood, vol. 64, pp. 400-405 (1984).
Spiess, B. D., et al., "Protection from Cerebral Air Emboli With Perfluorocarbons in Rabbits", Stroke, vol. 17, pp. 1146-1149 (1986).
Kanter, K. R., et al., "Superiority of Perfluorocarbon Cardioplegia Over Blood or Crystalloid Cardioplegia", Circulation, vol. 64, pp. II-75-II-80 (1981).
Harjula, A., et al., "Perfluorocarbon Solution as a Myocardial Preservative", J. Applied Cardiology, vol. 2, pp. 121-136 (1987).
Tokioka, M. D., et al., "Effects of Intracoronary Infusion of Arterial Blood or Fluosol-DA 20% on Regional Myocardial Metabolism and Function During Brief Coronary Artery Occlusions", Laboratory Investigation, vol. 75, pp. 473-481 (1987).
Benner, K. U., et al., "Uber die Wirkung von Pluronic.RTM. F-68, einem Poloxypropylen-Polyoxyyyathylen-Kondensat, auf die ADP-induzierte Thrombocytenaggregation in vitro", Plugers Arch., vol. 315, pp. 45-52.
Forman, M. B., et al., "Reduction of Infarct Size with Intracoronary Perfluorochemical in a Canine Preparation of Reperfusion", Circulation, vol. 71, pp. 1060-1068 (1985).
Forman, M. B., et al., "Beneficial Long-Term Effect of Intracoronary Perfluorochemical on Infarct S

Affiliated with

Also associated with

Rating

Method of treating tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating tumors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1490822