Urea derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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424324, 564 26, 564 28, 564 29, 564 47, 564 52, 564 63, 26050117, 8161, A61K 3117, A61K 31165

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044606028

ABSTRACT:
A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein n=1 or 0; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is OCH.sub.3, and wherein R.sub.2 is OH. These urea derivatives have analgesic and anti-irritant activity when administered to humans and lower animals.

REFERENCES:
patent: 2663730 (1953-12-01), Hill et al.
patent: 2960488 (1960-11-01), Tamblyn et al.
patent: 3268582 (1966-08-01), Zeile et al.
patent: 3297726 (1967-01-01), Zecher et al.
patent: 3483296 (1969-12-01), Martin et al.
patent: 3488376 (1970-01-01), Ulrich
patent: 3636104 (1972-01-01), Kober et al.
patent: 3734961 (1973-05-01), Englehardt
patent: 3852339 (1974-12-01), Krapcho
patent: 3852348 (1974-12-01), Teach
patent: 4238508 (1980-12-01), Nelson
patent: 4313958 (1982-02-01), LaHann
Lange et al., "Some Ureas and Thioureas Derived from Vanillylamine Relations Between Constitution and Taste of Pungent Principles," J. Am. Chem. Soc., vol. 51, (1929), pp. 1911-1914.
Kiernan, "A Study of Chemically Induced Acute Inflammation in the Skin of the Rat", Quart. J. Exp. Physiol., vol. 62, (1977), pp. 151-161.
Jansco et al., "Direct Evidence for Neurogenic Inflammation and its Prevention by Denervation and by Pretreatment with Capsaicin," Br. J. Pharm. Chemother., vol. 31, (1967), pp. 138-151.
Arvier et al., "Modification by Capsaicin and Compound 40/80 of Dye Leakage Induced by Irritants in the Rat," Br. J. Pharm., vol. 59, (1977), pp. 61-68.
Yaksh et al., "Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces Prolonged Thermal Analgesia," Science, vol. 260, (1979), pp. 481-483.
Virus et al., "Pharmacologic Actions of Capsaicin: Apparent Involvement of Substance P and Serotonin," Life Sciences, vol. 24, (1979), pp. 1273-1281.
Jones et al., "The Relation Between Chemical Constitution and Pungency in Acid Amides," J. Chem. Soc., vol. 27, (1925), pp. 2588-2598.
Newman, "Natural and Synthetic Pepper-Flavored Substances," Chem. Prod., (Mar. 1954), pp. 102-106.
Szolesanyi et al., "Sensory Effects of Capsaicin Congeners," Arzneim.-Forsch., vol. 25, (1975), pp. 1871-1881.
Szolesanyi et al., "Sensory Effects of Capsaicin Congeners," Arzneim.-Forsch., vol. 26, (1976), pp. 33-37.
Hegyes et al., "Synthesis of Homovanillic Acid Derivatives of Capsaicin-Like Effect," Acta. Phys. Chem., vol. 20, (1974), pp. 115-120.
Michalska et al., "Synthesis and Local Anesthetic Properties of N-Substituted 3,4-Dimethoxyphenethylamine Derivatives," Diss. Pharm. Pharmacol., vol. 24, (1972), pp. 17-25, (Chem. Abs. 77:19271a).
T. Szeki, "Contributions Towards Understanding the Relation Between the Chemical Constitution and the Sharp Taste of Acylamines," Arch. Pharm., vol. 268, (1930), pp. 151-157.

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