Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceu

Details Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceu Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceu

1980-02-04

1981-05-19

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546 17, 546208, 2603265CA, 26032634, 26032638, 2603264, 2603265D, 2603265A, 2603265C, C07D52100, A61K 31445, A61K 31395

Patent

active

042685150

ABSTRACT:
The invention relates to spiro[dihydrobenzofuran-piperidines and -pyrrolidines] of the formula ##STR1## wherein R is the hydrogen atom, alkyl, alkoxycarbonyl, phenoxycarbonyl, cyano, aralkyl, alkanoyl, aralkanoyl, hydroxyalkyl, benzoylalkyl, ##STR2## where p is an integer of 2 or 3 and R.sub.1 and R.sub.2 are the same or different and are hydrogen and alkyl; X is hydrogen and alkyl; Hal is a halogen and q is an integer of 0 or 1; m is an integer of 1 or 2, n is an integer of 1, 2 or 3, where the sum of m and n is 3 or 4; and the pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 3686186 (1972-08-01), Houlihan et al.
patent: 3959475 (1976-05-01), Bauer et al.
patent: 3962259 (1976-06-01), Bauer et al.
patent: 4166119 (1979-08-01), Effland et al.
patent: 4166120 (1979-08-01), Effland et al.
Inubushi et al., Chemical and Pharmaceutical Bulletin (Japan), vol. 12, pp. 749-753 (1964).

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