Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1983-04-01
1984-07-17
Padgett, Benjamin R.
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
A61M 700
Patent
active
044603720
ABSTRACT:
A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed a therapeutically effective rate.
REFERENCES:
patent: 3731683 (1973-05-01), Zaffaroni
patent: 3797494 (1974-03-01), Zaffaroni
patent: 4060084 (1977-11-01), Chandrasekaran
patent: 4096239 (1978-06-01), Katz et al.
patent: 4230105 (1980-10-01), Harwood
patent: 4286592 (1981-09-01), Chandrasekaran
patent: 4291014 (1981-09-01), Keith et al.
Campbell Patricia S.
Chandrasekaran Santosh K.
ALZA Corporation
Mandell Edward L.
Padgett Benjamin R.
Sabatine Paul L.
Stone Steven F.
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