Prodrugs for improved bioavailability of certain .DELTA..sup.4 -

Details Prodrugs for improved bioavailability of certain .DELTA..sup.4 - Prodrugs for improved bioavailability of certain .DELTA..sup.4 -

1979-07-13

1981-05-19

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424241, A61K 3158, C07J 3300

Patent

active

042684412

ABSTRACT:
Transient, orally active thiazolidine type prodrug forms of conventional, natural and synthetic ketosteroidal sex hormones, e.g., of progesterone, testosterone, and the like, are disclosed. The subject compounds can be prepared by known methods, for example, by reacting the corresponding 3-keto or 3,20-diketo steroids with a thiazolidine-forming reagent such as an L-cysteine alkyl ester.

REFERENCES:
patent: 4069322 (1978-01-01), Bodor et al.

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