Process for the preparation of protected dihydroxypropyl trialky

Details Process for the preparation of protected dihydroxypropyl trialky Process for the preparation of protected dihydroxypropyl trialky

1999-05-27

2000-07-04

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

558 45, 558 47, 558 48, 558136, 558166, 549451, 549452, 560253, 564292, C07C20912, C07C30330, C07D31728

Patent

active

060841311

ABSTRACT:
A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of (2,2-dimethyl-1,3-dioxolan-4-ylmethyl)trialkylammonium salts, particularly in chiral form is described. Furthermore, a process is described wherein the (2,2-dimethyl-1,3-dioxolan-4ylmethyl)trialkylammonium salts is a 2,2-dimethyl-1,3-dioxolan-4-ylmethyl trimethylammonium salt, preferably in chiral form. The protected dihydroxypropyl trialkylammonium salts lead to L-carnitine (9) when in chiral form (5).

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Takemura, Chem Abstr. 101:203881, 1984.
Morishita et al., Chem Abst. 109:92507, 1988.

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