Synthesis of 3-carbomethoxy-4,5-dimethylthiophene

Details Synthesis of 3-carbomethoxy-4,5-dimethylthiophene Synthesis of 3-carbomethoxy-4,5-dimethylthiophene

1998-10-13

2000-07-04

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 62, 549 64, 549 71, 549 57, C07D33338, C07D33332, C07D33356

Patent

active

060841087

ABSTRACT:
Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.

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