Phenylenediamine derivative, radical scavenger, brain-infarction

Details Phenylenediamine derivative, radical scavenger, brain-infarction Phenylenediamine derivative, radical scavenger, brain-infarction

1998-06-02

2000-07-04

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514602, 514613, 514617, 514622, 564 88, 564 90, 564 92, 564169, 564171, 564175, 564176, 564182, 564183, A61K 31166, A61K 3118, C07C30700, C07C23542

Patent

active

060839872

ABSTRACT:
A phenylenediamine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CO--, --CH.sub.2 CO--, --CS--, or --SO.sub.2 --; Y represents a carbon atom or nitrogen atom; R.sub.1 represents a lower alkyl group; R.sub.2 represents a hydrogen, lower alkyl, alkenyl, benzyl, or benzoyl group; and each of R.sub.3 and R.sub.4 represents an alkyl group having 1-10 carbon atoms. The phenylenediamine derivative above mentioned, as a radical scavenger, has antioxidant effect and lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.

REFERENCES:
Klosa, J. Praket. Chem. 19(4), 45-55(1963) (With Chemical Abstract 11349), German language, 1963.
Gupta,, Gupta, Search for New Local Anaesthetics. Part IV, English Language, J. Indian Chem. Soc. 34.528-530(1957).
Hassner et al., , Synthetic Methods. Part 23 Rearrangement of Some Hydroxamic Acids Into Amides. A Self-Condensation Leading to Disproportionation English Language, J. Chem. Soc. Perkin. Trans. 733-737(1988).
Shiseido Co., Ltd., Abstract, Jap. Patent Application 07344947, Jun. 17, 1997.

Affiliated with

Also associated with

Rating

Phenylenediamine derivative, radical scavenger, brain-infarction does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenylenediamine derivative, radical scavenger, brain-infarction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylenediamine derivative, radical scavenger, brain-infarction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1487024