Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
2000-07-04
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514912, 549401, 549403, A61K 3135, C07D31174, C07D31176
Patent
active
060839775
ABSTRACT:
Novel trienoic retinoid compounds having activity for retinoic acid receptors and retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their use.
REFERENCES:
patent: 4472430 (1984-09-01), Loev et al.
patent: 4534979 (1985-08-01), Loev et al.
patent: 4648996 (1987-03-01), Aig et al.
patent: 4894480 (1990-01-01), Aig et al.
patent: 5320833 (1994-06-01), Deckers et al.
patent: 5705167 (1998-01-01), Bernardon et al.
Chem Abst. vol. 75 No. 48 745, Badr et al "Resuable navigator of allyl aromatics" 1971.
Aurell, M., et al., "Trienediolates of Hexadienoic Acids in Synthesis. Synthesis of Retinoic and nor-Retinoic Acids." Tetrahedron, vol. 49, 27:6089-6100 (1993).
Boehm, M., et al., "Synthesis of High Specific Activity [.sup.3 H]-cis-Retinoic Acid and Its Application for Identifying Retinoids with Unusual Binding Properties," Journal of Medicinal Chemistry, vol. 37, 3:408-414 (1994).
Boehm, M., et al., "Synthesis and Structure--Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids," Journal of Medicinal Chemistry, vol. 37, 18:2930-2941 (1994).
Liu, R., et al., "Photochemistry and Synthesis of Stereoisomers of Vitamin A," Tetrahedron, vol. 40, 11:1931-1969 (1984).
Kagechika, H., et al., "Retinobenzoic Acids. 4. Conformation of Aromatic Amides with Retinoidal Activity. Importance of trans-Amide Structure for the Activity," Journal of Medicinal Chemistry, vol. 32, 2292-2296 (1989).
Kagechika, H., et al., "Retinobenzoic Acids. 3. Structure-Activity Relationships of Retinoidal Azobenzene-4-carboxylic Acids and Stilbene-4-carboxylic Acids," Journal of Medicinal Chemistry, vol. 32, 1098-1108 (1989).
Kagechika, H., et al., "Retinobenzoic Acids. 2. Structure-Activity Relationships of Chalcome-4-carboxylic Acids and Flavone-4'-carboxylic Acids," Journal or Medicinal Chemistry, vol. 32, 834-840 (1989).
Boehm Marcus F.
Nadzan Alex M.
Zhang Lin
Covington Raymond
Elmer J. Scott
Kight John
Ligand Pharmaceuticals Incorporated
Respess William L.
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