Preparation of 3-methylpiperidine

Details Preparation of 3-methylpiperidine Preparation of 3-methylpiperidine

1975-06-27

1976-08-17

Milestone, Norma S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D29502

Patent

active

039753921

ABSTRACT:
There is disclosed a process for the preparation of 3-methylpiperidine which comprises a multi-stage hydrogenation of .alpha.-methylene glutaronitrile using as a catalyst a highly dispersed nickel in which the first stage hydrogenation is conducted at temperature ranging from about 20.degree.C to about 50.degree.C at hydrogen pressure of at least 14 kilograms per square centimeter to form .alpha.-methyl glutaronitrile. The second stage hydrogenation is conducted at temperatures ranging from about 80.degree.C to about 175.degree.C at hydrogen pressures of at least 42 kilograms per square centimeter to form 2-methyl-1,5-diaminopentane. At which time the reaction mixture is cooled to a temperature below the boiling point of any of the materials present in the process and all the excess hydrogen vented off. The temperature is then increased to at least about 150.degree.C to allow the 2-methyl-1,5-diaminopentane to cyclize to form 3-methylpiperidine.

REFERENCES:
patent: 2790804 (1957-04-01), Silverstone
patent: 3350439 (1967-10-01), Feldman et al.

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