Inhibitory octapeptides angiotensin II

Details Inhibitory octapeptides angiotensin II Inhibitory octapeptides angiotensin II

1975-01-27

1976-08-17

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

039753654

ABSTRACT:
Octapeptide derivatives characterized by an oxygen or sulfur-containing moiety in the C-terminal position are potent inhibitors of the pharmacological effects of Angiotensin and possess the additional advantage of a favorable antagonist/agonist ratio.

REFERENCES:
patent: 3886134 (1975-05-01), Sipos et al.
Khairallah et al., J. Med. Chem., 13, 181-184 (1970).

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