Programmed cell death genes and proteins

Details Programmed cell death genes and proteins Programmed cell death genes and proteins

1994-06-10

2000-07-04

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4353201, 4352523, 424 9467, 530350, 536 232, 536 235, C12N 964

Patent

active

060837357

ABSTRACT:
This invention relates to proteins encoded by the cell death genes that are involved in regulating programmed cell death. In particular, the invention describes the cell death protein Ich-1 (Caspase-2) and its alternative splicing products Ich-1.sub.L and Ich-1.sub.S. Methods for controlling programmed cell death by regulating the activity of the cell death gene products are also described.

REFERENCES:
patent: 5360893 (1994-11-01), Owens et al.
Dinarello, C.A., "Interleukin-1.sup.a," Ann N.Y. Acad. Sci., 546:122-132 (Dec. 1998).
Sarih, M., et al., "Silica induces apoptosis in macrophages and the release of interleukin-1.alpha. and interleukin-1.beta.," J. Leukoc. Biol., 54(3):407-413 (Nov. 1993).
Zychlinsky, A., et al., "Interleukin-1 is released by Murine Macrophages during Apoptosis Induced by Shigella flexneri," J. Clin. Invest., 94(3):1328-1332 (Sep. 1994).
Black, R.A., et al., "A Pre-aspertate-specific Protease from Human Leukocytes That Cleaves Pro-interleukin-1.beta.," J. Biol. Chem. 264(10):5323-5326 (1989).
Bruno, S., et al., "Inhibitors of Proteases Prevent Endonucleolysis Accompanying Apoptotic Death of HL-60 Leukemic Cells and Normal Thymocytes," Leukemia 6(11):1113-1120 (Nov. 1992).
Hockenbery, D., et al., "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death," Nature 348:334-336 (1990).
Komiya, T., et al., "Inhibition of Interleukin-1.beta. Converting Enzyme by the Cowpox Virus Serpin CrmA," J. Biol. Chem. 269(30):19331-19337 (Jul. 1994).
Tewari, M., and Dixit, V.M., "Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product," J. Biol. Chem. 270(7):3255-3260 (Feb. 1995).
International Search Report for Patent Application No. PCT/US94/06630 (attached cited reference: UEMBL, Accession No. D28492 and D10713, issued Jun. 4, 1994, Kumar et al., "Mouse mRNA for Nedd2 protein"; sequence).
Barinaga, M., "Cell Suicide: By ICE, Not Fire," Science 263:754-756 (Feb. 1994).
Barinaga, M., "Death Gives Birth ot the Nervous System. But How?," Science 259:762-763 (Feb. 1993).
Bhakdi, S., et al., "Effects of Escherichia coli Hemolysin on Human Monocytes. Cytocidal Action and Stimulation of Interleukin 1 Release," J. Clin. Invest. 85:1746-1753 (1990).
Black, R.A. et al., "Activation of interleukin-1.beta. by a co-induced protease," FEBS Letters 247(2):386-390 (1989).
Cerretti, D.P. et al., "Molecular Cloning of the Interleukin-1.beta. Converting Enzyme," Science 256:97-100 (Apr. 3, 1992).
Edgington, S.M., "Looking Death In The Eye: Apoptosis And Cancer Research," Bio/Technology 11:787-792 (Jul. 1993).
Ellis, H.M. et al., "Genetic Control of Programmed Cell Death in the Nematode C. elegans," Cell 44:817-829 (1986).
Ellis, R.E. et al., "Genes Required for the Engulfment of Cell Corpses During Programmed Cell Death in Caenorhabditis elegans," Genetics 129:79-94 (1991).
Ellis, R.E. et al., "Two C. elegans genes control the programmed deaths of specific cells in the pharynx," Development 112:591-603 (1991).
Gagliardini, V. et al., "Prevention of Vertebrate Neuronal Death by the crmA Gene," Science 263:826-828 (Feb. 1994).
Hengartner, M.O. et al., "Caenorhabditis elegans gene ced-9 protects cells from programmed cell death," Nature 356:494-499 (Apr. 9, 1992).
Hodgson, C.P., "The Vector Void in Gene Therapy," Bio/Technology 13:222-225 (Mar. 1995).
Hogquist, K.A. et al., "Interleukin 1 is processed and released during apoptosis," Proc. Natl. Acad. Sci. USA 88:8485-8489 (1991).
Jacobson, M.D. et al., "Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA," Nature 361:365-369 (Jan. 28, 1993).
Kostura, M.J. et al., "Identification of a monocyte specific pre-interleukin 1.beta. convertase activity," Proc. Natl. Acad. Sci. USA 86:5227-5231 (1989).
Kumar, S. et al., "Identification of a Set of Genes with Developmentally Down-Regulated Expression in the Moues Brain," Biochem. Biophys. Res. Comm. 185(3):1155-1161 (Jun. 1992).
Marx, J., "Cell Death Studies Yield Cancer Clues," Science 259:760-761 (Feb. 1993).
Miura, M. et al., "Induction of Apoptosis in Fibroblasts by IL-1.beta.-Converting Enzyme, a Mammalian Homolog of the C. elegans Cell Death Gene ced-3," Cell 75:653-660 (Nov. 1993).
Miura, M. et al., "Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway," Proc. Natl. Acad. Sci USA 92:8318-8322 (Aug. 1995).
Nett, M.A. et al., "Molecular Cloning Of The Murine IL-1.beta. Converting Enzyme cDNA," J. Immunol. 149(10):3254-3259 (Nov. 15, 1992).
Nunez, G. et al., "Deregulated Bcl-2 Gene Expression Selectively Prolongs Survival Of Growth Factor-Deprived Hemopoietic Cell Lines," J. Immunol. 144(9)3602-3610 (1990).
Oltvai, Z.N. et al., "Bcl-2 Heterodimerizes In Vivo with a Conserved Homolog, Bax, That Accelerates Programed Cell Death," Cell 74:609-619 (Aug. 1993).
Ray, C.A. et al., "Viral Inhibition of Inflammation: Cowpox Virus Encodes an Inhibitor of the Interleukin-1.beta. Converting Enzyme," Cell 69:597-604 (May 15, 1992).
Sentman, C.L. et al., "bcl-2 Inhibits Multiple Forms of Apoptosis but Not Negative Selection in Thymocytes," Cell 67:879-888 (1991).
Strasser, A. et al., "bcl-2 Transgene Inhibits T Cell Death and Perturbs Thymic Self-Censorship," Cell 67:889-899 (1991).
Thornberry, N.A. et al., "A novel heterodimeric cysteine protease is required for interleukin-1.beta. processing in monocytes," Nature 356:768-774 (Apr. 30, 1992).
Ulhmann, E. and Peyman, A., "Antisense Oligonucleotides: A New Therapeutic Principle," Chem. Rev. 90(4):544-584 (1990).
Vaux, D.L. et al., "Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2," Science 258:1955-1957 (Dec. 18, 1992).
Wang, L. et al., "Ich-1, an IceIced-3-Related Gene, Encodes Both Positive and Negative Regulators of Programmed Cell Death," Cell 78:739-750 (Sep. 1994).
Yuan, J. et al., "The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death," Development 116:309-320 (Oct. 1992).
Yuan, J. et al., "The Caenorhbditis elegans Genes ced-3 and ced-4 Act Cell Autonomously to Cause Programmed Cell Death," Developmental Biology 138:33-41 (1990).
Yuan, J. et al., "The C. elegans Cell Death Gene ced-3 Encodes a Protein Similar to Mammalian Interleukin-1.beta.-Converting Enzyme," Cell 75:641-652 (Nov. 1993).

Affiliated with

Also associated with

Rating

Programmed cell death genes and proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Programmed cell death genes and proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Programmed cell death genes and proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1485224