Process for preparing pyrrolo[1,2-a]imidazoles and imidazo[1,2-a

Details Process for preparing pyrrolo[1,2-a]imidazoles and imidazo[1,2-a Process for preparing pyrrolo[1,2-a]imidazoles and imidazo[1,2-a

1984-11-23

1985-12-24

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548453, C07D47100

Patent

active

045607583

ABSTRACT:
The instantly claimed invention is a process for preparing a 3-aryl or a 2,3-diaryl-2,5,6,7-tetrahydro-3H-pyrrole[1,2-a]imidazole or a 3-aryl or a 2,3-diaryl-2,3,5,6,7,8-hexa-hydroimidazo[1,2-a]pyridine which comprises (a) contacting the acid addition salt of the corresponding cyclic methylthioimine with a 2-aryl or a 2,3-diarylaziridine and (b) recovering from the resultant reaction mixture the desired compound, useful as immunomodulators.

REFERENCES:
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Merck Index, 9th Edition, No. 8949 (Levamisole).
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Chem. Abstracts, 67, 72351w (U.S.S.R.).
Chem. Abstracts, 70, 77908e (U.S.S.R.).
Chem. Abstracts, 87, 168031f (Merck).
P. G. Gassman et al., J. Org. Chem., vol. 42, pp. 3236-3240 (1977).
P. A. Zoretic et al., J. Org. Chem., vol. 41, pp. 3587-3589 (1976).
H. Mohrle et al., Z. Naturforsch, 31b, 99-105 (1976).
L. Werbel et al., J. Het. Chem., vol. 2, p. 287 (1965).

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