Cephem-3-imidates and 3-amidines

Details Cephem-3-imidates and 3-amidines Cephem-3-imidates and 3-amidines

1983-11-18

1985-12-24

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 19, 544 20, 544 22, 544 26, C07D50118

Patent

active

045607494

ABSTRACT:
3-Azido-3-cephem esters are reacted with electron rich olefins, e.g., enamines and cyclic enol ethers, to provide C.sub.3 amidines and imidates having antibacterial activity in the free acid form. For example, 3-azido-3-cephem esters react with ethyl vinyl ether to provide 3-[1-(ethoxyethylidene)amino]-3-cephem esters. The latter are deesterified to provide the free acid antibacterials.

REFERENCES:
patent: 4001226 (1977-01-01), Spry
patent: 4101658 (1978-07-01), Yoshioka
patent: 4307233 (1981-12-01), Farge

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