Method for purifying N-benzyloxycarbonyl aspartic acid

Details Method for purifying N-benzyloxycarbonyl aspartic acid Method for purifying N-benzyloxycarbonyl aspartic acid

1983-04-07

1984-05-22

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C12506

Patent

active

044502842

ABSTRACT:
N-benzyloxycarbonyl aspartic acid containing minor contaminating amounts of N-benzyloxycarbonyl aspartyl aspartic acid is purified by subjecting the impure material to alkaline hydrolysis at a pH of from 10 to 12 and at temperatures of from 30.degree. C. to 100.degree. C., preferably 65.degree. C. to 90.degree. C., for a time sufficient to hydrolyze substantially all of the N-benzyloxycarbonyl aspartyl aspartic acid impurity therein. N-benzyloxycarbonyl aspartic acid containing less than 0.2 weight percent of the impurity can be obtained by such treatment.

REFERENCES:
patent: 3492131 (1970-01-01), Schlatter
patent: 3808190 (1974-04-01), Dahlmans et al.
patent: 4293706 (1981-10-01), Gorman et al.
patent: 4345091 (1982-08-01), Sugiyama et al.
Berichte d.D. Chem. Gesellschaft, vol. 65, pp. 1192-1201, 1197 (1932), "Concerning a Universal Process for the Synthesis of Peptides", by Max Bergmann et al.
Houben-Weyl, vol. XV/1, p. 321 (1974).

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