Process for the preparation of 1,3,7-trialkyl xanthines and di(3

Details Process for the preparation of 1,3,7-trialkyl xanthines and di(3 Process for the preparation of 1,3,7-trialkyl xanthines and di(3

Filed on

1981-10-02

Date issued

1984-05-22

Examiner

Lee, Mary C.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Antigen, epitope, or other immunospecific immunoeffector

SubSubClass

Bacterium or component thereof or substance produced by said...

Other Related Categories

544271, 544273, C07D47312, A61K 3152

Type

Patent

Status

active

Patent number

044501633

Description

ABSTRACT:
The invention relates to a process for the preparation of 1,3,7-trialkyl xanthines, i.e. xanthines completely substituted on the nitrogen atoms, by the N-alkylation of xanthines by phase transfer catalysis. Some of the trialkyl xanthines obtained are new and di(3,7-dimethylxanthin-1-yl)methane is described as a medicament having immunosupressant properties.

REFERENCES:
patent: 631757 (1899-08-01), Fritz
patent: 631760 (1899-08-01), Fritz
patent: 2523496 (1950-09-01), Campbell et al.
patent: 3740433 (1973-06-01), Clody et al.
Klingler; Chemikar-Zeitung; 96, pp. 424-432. (1972).
Gokol; Jour. of Chemical Education, vol. 55, pp. 350-354 (1978).
Chem. Abs. vol. 49:9045h (1954) (Abstract of British Pat. 706424).

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