Process and intermediates for the preparation of aryl substitute

Details Process and intermediates for the preparation of aryl substitute Process and intermediates for the preparation of aryl substitute

1984-04-06

1985-12-24

Michl, Paul R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D47104

Patent

active

045605106

ABSTRACT:
A process for preparing pyrido[1,4]benzodiazepines having antidepressant activity illustrated by the formula: ##STR1## wherein Ar is pyridinyl, thienyl or phenyl; R is alkali-metal ion, hydrogen, loweralkyl or an amine or an amine precursor on the end of a hydrocarbon chain and wherein in the process condensation of an amino-chloropyridine with an aryl(aminophenyl)methanone is accomplished with a strong non-nucleophilic base in stirrable admixture with an inert liquid carrier. Alternatively, condensation is accomplished sequentially using titanium tetrachloride first followed by non-nucleophilic base.

REFERENCES:
patent: 4447361 (1984-05-01), Taylor
patent: 4480100 (1984-10-01), Lo

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