Substituted 7-oxomitosanes

Details Substituted 7-oxomitosanes Substituted 7-oxomitosanes

1990-02-26

1992-03-17

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548422, C07D48704, A61K 3140

Patent

active

050970364

ABSTRACT:
The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group. Mitomycin A is an antibiotic of established utility, and the 7-O-substituted mitosane analogs thereof have similar utility.

REFERENCES:
patent: 4814445 (1989-03-01), Vyas et al.
patent: 4888341 (1989-12-01), Remers et al.
patent: 4927943 (1990-05-01), Vyas et al.

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