Pyrrolidine derivatives

Details Pyrrolidine derivatives Pyrrolidine derivatives

1990-03-13

1992-03-17

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514340, 546275, 548568, 544408, 544336, A61K 3140, C07D20708

Patent

active

050968904

ABSTRACT:
Compounds of the formula ##STR1## wherein R, Y and R.sup.1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altered motility on tone of smooth muscle, including irritable bowel syndrome, diverticular disease, urinary incontinence, oesophageal achalasia and chronic obstructive airways disease.

REFERENCES:
patent: 3403159 (1968-09-01), Pesson
patent: 4002766 (1977-01-01), Welstead
patent: 4242261 (1980-12-01), Cale

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