Novel 1.alpha.-hydroxy-24-oxovitamin D.sub.3, its preparing proc

Details Novel 1.alpha.-hydroxy-24-oxovitamin D.sub.3, its preparing proc Novel 1.alpha.-hydroxy-24-oxovitamin D.sub.3, its preparing proc

1978-09-01

1980-04-22

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603972, C07J 900

Patent

active

041995775

ABSTRACT:
Novel 1.alpha.,3.beta.-dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof.
Said novel 1.alpha.-hydroxy-24-oxovitamin D.sub.3 and said novel intermediates are also useful as the intermediates of 1.alpha.,24-dihydroxyvitamin D.sub.3.
1.alpha.,3.beta.-Dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof are prepared from fucosterol via 1.alpha.,3.beta.-diprotected hydroxy-24(24)-ethylenedioxycholest-5-ene. 1.alpha.-hydroxy-24-oxovitamin D.sub.3 is prepared by irradiation with ultraviolet rays to 1.alpha.,3.beta.-dihydroxy-24-oxocholesta-5,7-diene or a hydroxyl group-protected derivatives thereof, isomerization using heat energy, and, when necessary, elimination of the protecting groups.

REFERENCES:
patent: 3833622 (1974-09-01), Babcock et al.
patent: 4165660 (1978-08-01), Jones

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