Monoclonal antibodies for diagnosis of hairy cell leukemia

Details Monoclonal antibodies for diagnosis of hairy cell leukemia Monoclonal antibodies for diagnosis of hairy cell leukemia

1986-03-11

1992-03-17

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

43524027, 4351722, 436548, 436813, 530387, 530808, 530809, 935103, 935110, G01N 33574, G01N 3353, C07K 1528, C12N 512

Patent

active

050968106

ABSTRACT:
Monoclonal antibodies are described which are potent reagents for the immunologic definition of hairy leukemic cells.
S-HCL 1 is a pan-B cell marker with markedly increased staining on hairy cells versus normal B-lymphocytes. It also stains with a variety of B-cell leukemias and lymphomas, but is not crossreactive with any other cell type in man. With these features, it is also a useful reagent for the detection of human B-lymphocytes.
S-HCL-3 monoclonal antibody recognizes an antigen present on entirely different cell lineages, namely macrophages of almost all tissues and polymorphonuclear cells. This antigen is not expressed on any other malignant lymphocytes except hairy cells. Moreover, this antigen is not found on other non-Hodgkin lymphomas which may resemble hairy cell leukemia. Accordingly, b-HCl-3 is useful in the diagnosis of hairy cell leukemic.

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Brooks et al., J. Immunol., 126(4):1373-1377 (1981).
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