Peptides related to somatostatin

Details Peptides related to somatostatin Peptides related to somatostatin

1978-11-20

1980-04-22

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

041995007

ABSTRACT:
The tetradecapaptides of the formula ##STR1## wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly, or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit the secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. Intermediates used in the synthesis of the tetradecapeptides are also described.

REFERENCES:
patent: 3904594 (1975-09-01), Guillemin et al.
patent: 4061607 (1977-12-01), Shields
patent: 4061626 (1977-12-01), Shields
patent: 4062816 (1977-12-01), Shields
patent: 4076659 (1978-02-01), Shields
patent: 4077952 (1978-03-01), Sarantakis
patent: 4087390 (1978-05-01), Shields
patent: 4100117 (1978-07-01), Shields
patent: 4123425 (1978-10-01), Garsky
Rivier et al., Peptides 1976, 427-451.

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